Evidence map›Paper›PMID 39498195›Full record

ArticleIJU case reports2024

Severe neutropenia caused by palliative radiation therapy in a case of metastatic hormone-sensitive prostate cancer.

Fumisato Maesaka, Atsushi Tomioka, Chie Matsushita, Noriko Horikawa, Kiyohide Fujimoto

Abstract read
In one paragraph

Article in IJU case reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Fumisato MaesakaDepartment of Urology Saiseikai Chuwa Hospital Nara Japan.ORCID https://orcid.org/0000-0001-7754-7184
Atsushi TomiokaDepartment of Urology Saiseikai Chuwa Hospital Nara Japan.
Chie MatsushitaDepartment of Urology Saiseikai Chuwa Hospital Nara Japan.
Noriko HorikawaDepartment of Radiation Oncology Saiseikai Chuwa Hospital Nara Japan.
Kiyohide FujimotoDepartment of Urology Nara Medical University Nara Japan.ORCID https://orcid.org/0000-0003-1507-2464

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Radiotherapy for widespread bone metastasis results in severe hematological toxicity. Case presentation: A 71-year-old male was diagnosed with metastatic hormone-sensitive prostate cancer (cT4N1M1b) and treated with apalutamide and degarelix. Concurrently, palliative radiation therapy was sequentially initiated for the 1st, 5th, and 10th thoracic vertebrae and right femur. On day 35 after treatment, severe neutropenia necessitated treatment interruption and required 23 days for neutrophil recovery with a granulocyte colony-stimulating factor agent. Conclusion: Owing to the severe hematologic toxicity caused by extensive radiation therapy for multiple bone lesions, treatment prioritization by lesion and avoiding irradiation of the red bone marrow is essential.

Indexed as

bone metastasisneutropeniapalliative radiation therapyprostate cancerred bone marrow

Identifiers

PMID39498195
PMCPMC11531869

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.