Evidence map›Paper›PMID 39498172›Full record

ArticleOpen forum infectious diseases2024

Evaluation of Primary Oral Vancomycin Prophylaxis Against

Michael J Williams, Sol Atienza, Erin Franzen, Heena Rathod, Brittany Mejaki, Justin Graff, Sandra Korman, Noah Zouine, Zartash Gul, Sherjeel Sana and 2 more

Abstract read
In one paragraph

Article in Open forum infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Oral Vancomycin to PreventOpen forum infectious diseases · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Michael J WilliamsMalignant Hematology and Stem Cell Transplant, Aurora St Luke's Medical Center, Milwaukee, Wisconsin, USA.ORCID https://orcid.org/0000-0002-4503-6707
Sol AtienzaDepartment of Pharmacy, Aurora St Luke's Medical Center, Milwaukee, Wisconsin, USA.
Erin FranzenDepartment of Pharmacy, Aurora St Luke's Medical Center, Milwaukee, Wisconsin, USA.
Heena RathodDepartment of Pharmacy, Aurora St Luke's Medical Center, Milwaukee, Wisconsin, USA.
Brittany MejakiMalignant Hematology and Stem Cell Transplant, Aurora St Luke's Medical Center, Milwaukee, Wisconsin, USA.ORCID https://orcid.org/0009-0002-9679-4978
Justin GraffMalignant Hematology and Stem Cell Transplant, Aurora St Luke's Medical Center, Milwaukee, Wisconsin, USA.ORCID https://orcid.org/0009-0008-0011-2113
Sandra KormanQuality Management, Aurora St Luke's Medical Center, Milwaukee, Wisconsin, USA.
Noah ZouineQuality Management, Aurora St Luke's Medical Center, Milwaukee, Wisconsin, USA.
Zartash GulMalignant Hematology and Stem Cell Transplant, Aurora St Luke's Medical Center, Milwaukee, Wisconsin, USA.
Sherjeel SanaMalignant Hematology and Stem Cell Transplant, Aurora St Luke's Medical Center, Milwaukee, Wisconsin, USA.
Stephen MedlinMalignant Hematology and Stem Cell Transplant, Aurora St Luke's Medical Center, Milwaukee, Wisconsin, USA.
Brian P BuggyInfectious Diseases Section, Aurora St Luke's Medical Center, Milwaukee, Wisconsin, USA.ORCID https://orcid.org/0000-0002-6015-5755

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Evaluations of oral vancomycin prophylaxis (OVP) against Methods: Patients who received an ASCT within our institution between 1 January 2012 and 31 December 2021 were included and separated into 2 groups based on the receipt of OVP. The primary study aim was to measure the incidence of Results: Overall, 254 patients were evaluated and 58% received OVP, predominantly as primary prophylaxis (95%). Of the 18 patients who developed in-hospital CDI, 6 were in the OVP group versus 12 in the non-OVP cohort (4% vs 11%, Conclusions: The use of OVP significantly reduced the incidence of CDI during the in-hospital ASCT course without increasing CDI post-OVP use. These encouraging results should promote further research into the use of OVP in ASCT.

Indexed as

autologous stem cell transplantationClostridioides difficile infectionoral vancomycin prophylaxis

Identifiers

PMID39498172
PMCPMC11532790

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.