Evidence map›Paper›PMID 39498129›Full record

SynthesisFrontiers in microbiology2024

Comparative analysis of the leprosy detection rate regarding its clinical spectrum through PCR using the

Marcos Jessé Abrahão Silva, Thiago Pinto Brasil, Caroliny Soares Silva, Cristiane Cunha Frota, Daniele Melo Sardinha, Luiza Raquel Tapajós Figueira, Keitty Anne Silva Neves, Everaldina Cordeiro Dos Santos, Karla Valéria Batista Lima, Nédia de Castilhos Ghisi and 1 more

Abstract readSystematic Review
In one paragraph

Synthesis in Frontiers in microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Marcos Jessé Abrahão Silva *Ph.D and Master Program in Parasitic Biology in the Amazon (PPGBPA), State University of Pará (UEPA), Belém, Pará, Brazil.
Thiago Pinto Brasil *Faculty of Medicine, Federal University of Ceará (UFC), Fortaleza, Ceará, Brazil.
Caroliny Soares SilvaPh.D and Master Program in Parasitic Biology in the Amazon (PPGBPA), State University of Pará (UEPA), Belém, Pará, Brazil.
Cristiane Cunha FrotaFaculty of Medicine, Federal University of Ceará (UFC), Fortaleza, Ceará, Brazil.
Daniele Melo SardinhaPh.D and Master Program in Parasitic Biology in the Amazon (PPGBPA), State University of Pará (UEPA), Belém, Pará, Brazil.
Luiza Raquel Tapajós FigueiraPh.D and Master Program in Parasitic Biology in the Amazon (PPGBPA), State University of Pará (UEPA), Belém, Pará, Brazil.
Keitty Anne Silva NevesPh.D and Master Program in Parasitic Biology in the Amazon (PPGBPA), State University of Pará (UEPA), Belém, Pará, Brazil.
Everaldina Cordeiro Dos SantosBacteriology and Mycology Section (SABMI), Evandro Chagas Institute (IEC), Ananindeua, Pará, Brazil.
Karla Valéria Batista LimaBacteriology and Mycology Section (SABMI), Evandro Chagas Institute (IEC), Ananindeua, Pará, Brazil.
Nédia de Castilhos GhisiPrograma de Pós-Graduação em Biotecnologia, Universidade Tecnológica Federal do Paraná (UTFPR), Dois Vizinhos, Paraná, Brazil.
Luana Nepomuceno Gondim Costa LimaBacteriology and Mycology Section (SABMI), Evandro Chagas Institute (IEC), Ananindeua, Pará, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Leprosy is a chronic and disabling infectious disease caused by Methods: This is a systematic review and meta-analysis study conducted according to the PRISMA 2020 guidelines, using the search descriptors with "AND": "Leprosy"; "Polymerase Chain Reaction"; " Results: The study was significant from the perspective of the paucibacillary group (Clinical biopsy: -0.45 [95% CI= -0.63 - -0.22], Conclusion: This implies little validation of it as a PCR target gene for diagnosing the disease, highlighting limitations in the actual technique. Systematic review registration: https://www.crd.york.ac.uk/prospero/, identifier CRD42024588790.

Indexed as

diagnosismultibacillary leprosyMycobacterium lepraepaucibacillary leprosypolymerase chain reaction

Identifiers

PMID39498129
PMCPMC11532149

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.