ArticleHeliyon2024
A 6-year retrospective study of olanzapine plasma concentration inpatients with schizophrenia CYP1A2 polymorphisms in real-life settings.
Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Association of Concomitant Amlodipine Use With Serum Olanzapine Concentrations and Clinical Outcomes in Patients With Schizophrenia.Human psychopharmacology · 2026Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aim: to investigate the potential influence of CYP1A2 polymorphisms on olanzapine plasma concentration of inpatients with schizophrenia in real-life settings. Methods: 409 inpatients who received OLA for at least 2 weeks, from June 2016 to March 2022 were included in the retrospective investigation. Moreover, 503 samples of above inpatients receiving OLA was built to investigate the influence of the relevant OLA plasma concentration, polymorphisms CYP1A2 -163C/A on the inpatients outcome. Results: Scale score reduction rate (SSRR) in 1 mutated CYP1A2 -163C/A alleles (CA) was significantly higher than other CYP1A2 alleles (CC + AA) (P = 0.002). Inverse S-curve correlations relationship was between SSRR and plasma concentrations of OLA (r = 0.130, P < 0.005). When remove ineffective subjects (ineffective group), the results of all CYP1A2 -163C/A genotype showed perfect correlations relationship tendencies with SSRR (r = 1.000). The best concentrations of OLA corrected for daily dose (C/D) range and the best concentration range of OLA of all CYP1A2 -163C/A genotype was 3.18-3.53 ng/mL/mg and 17.42-57.33 ng/mL. The C/D range and concentration range of OLA were 2.722-4.221 ng/mL/mg and 13.61-84.42 ng/mL, which belong CYP1A2 -163C/A CA genotype subjects, was largest. Conclusions: The best effective C/D range and concentration range of OLA respective were 3.18-3.53 ng/mL/mg and 17.42-57.33 ng/mL, which range values of CYP1A2 -163C/A CA genotype of inpatients with schizophrenia was largest.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.