ArticleSynlett : accounts and rapid communications in synthetic organic chemistry2024
Insights into the Regioselectivity of Metal-Catalyzed Aryne Reactions.
Article in Synlett : accounts and rapid communications in synthetic organic chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Synthesis of Unsymmetrical Carbazoles: A Mechanistic Cautionary Tale When UsingACS catalysis · 2026Article
- Article
- Investigations via Kinetics and Multivariate Linear Regression Models of the Mechanism and Origins of Regioselectivity in a Palladium-Catalyzed Aryne Annulation.ACS catalysis · 2024Article
- Nickel binding enables isolation and reactivity of previously inaccessible 7-aza-2,3-indolynes.Science (New York, N.Y.) · 2024Article
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Authors and funding
3 authors.
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Abstract
The synthetic potential of unsymmetrically substituted aryne intermediates is significantly hindered by regioselectivity issues. Current methods for inducing regioselectivity all rely on substrate control and are focused on non-metallated arynes. Before our initial disclosure, there was no systematic study regarding the regioselectivity of metal-catalyzed aryne reactions. By exploiting ligand control, we have induced regioselectivity in a palladium-catalyzed aryne annulation to form phenanthridinones (up to 9:91 r.r.). Through this study we have investigated: ligand effects, influence of steric perturbation, and the impact of the aryne precursor.
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