ArticleCureus2024
Hemophagocytic Lymphohistiocytosis (HLH): A Rare Complication of Dengue Hemorrhagic Fever.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dengue-associated hemophagocytic lymphohistiocytosis (HLH) is a rare presentation that can be potentially life-threatening, characterized by excessive activation of the immune system. This case report highlights the complexity of the presentation and management of a patient with multiple comorbidities who developed severe complications following a diagnosis of dengue fever. The patient presented with a persistent fever and abdominal pain alongside worsening renal and liver function. The combination of elevated serum triglyceride and ferritin levels, along with bicytopenia and the presence of splenomegaly, eventually led to a diagnosis of HLH. The patient required intensive care support, including hemodialysis, blood transfusions, and oxygen therapy. Treatment for HLH was initiated with high-dose dexamethasone and plasmapheresis, aiming to control the overactive immune response. This case highlights the need for awareness of HLH as a complication of dengue fever and emphasizes the significance of early diagnosis and treatment. It also stresses the need for further research to improve diagnostic and management strategies for HLH in dengue-endemic regions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.