Evidence map›Paper›PMID 39497565›Full record

ArticleJournal of Korean medical science2024

Genome-Wide Association Analysis of Rapid Decline in Lung Function: Analysis From the Korean Genome and Epidemiology Study.

Sang Hyuk Kim, Hyun Lee, Yong Suk Jo, Jaeeun Yoo, Joon Young Choi

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Article in Journal of Korean medical science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

5 authors.

Sang Hyuk KimDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Dongguk University Gyeongju Hospital, Dongguk University College of Medicine, Gyeongju, Korea.ORCID https://orcid.org/0000-0002-0410-8524
Hyun LeeDepartment of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-1269-0913
Yong Suk JoDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.ORCID https://orcid.org/0000-0002-6422-6530
Jaeeun YooDepartment of Laboratory Medicine, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.ORCID https://orcid.org/0000-0001-9917-5393
Joon Young ChoiDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. tawoe@naver.com.ORCID https://orcid.org/0000-0001-6298-2204

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA rapid decline in forced expiratory volume in 1 second (FEV1) is considered an important phenotype of the development of chronic obstructive pulmonary disease (COPD). However, the associations between specific genetic variants (single-nucleotide polymorphisms; SNPs) and this phenotype remain uncertain.

methodsWe enrolled 6,516 individuals from the Korean Genome and Epidemiology Study (KoGES). A rapid decline in FEV1 was defined as an annual decrease of FEV1 ≥ 60 mL/year. A multivariable logistic regression model was used to assess the associations between SNP variants and the rapid decline in FEV1. Considering the significant impact of smoking on lung function, a subgroup analysis based on smoking history was also conducted.

resultsA genome-wide association analysis of the rapid decline in FEV1 identified 15 association signals (

conclusionWe identified 15 nucleotide variants linked to a rapid decline in FEV1, including two SNPs previously reported to be associated with lung function development. Additional SNPs, which were associated with COPD, may be found using novel phenotypes.

Indexed as

Genome-Wide Association StudyPolymorphism, Single NucleotidePulmonary Disease, Chronic ObstructiveSmokingAdultAgedEast Asian PeopleFemaleForced Expiratory VolumeGenotypeHumansLogistic ModelsLungMaleMiddle AgedOdds RatioChronic ObstructiveGenetic TechniquesGenome-Wide Association StudyKoGESPulmonary DiseaseRespiratory Function TestsSpirometry

Identifiers

PMID39497565
PMCPMC11538576

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.