ArticleThe journal of headache and pain2024
Morphological similarity and white matter structural mapping of new daily persistent headache: a structural connectivity and tract-specific study.
Article in The journal of headache and pain, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Neuroregulatory mechanism of heat-sensitive moxibustion on the Dubi acupoint (ST 35) in patients with knee osteoarthritis: a resting-state functional magnetic resonance imaging study.Frontiers in neurologyTrial
- Pediatric New Daily Persistent Headache: Integrating Novel Research Methods to Support and Delineate Evolving Clinical Phenotypes.Children (Basel, Switzerland) · 2026Article
- ESM-AnatTractNet: Advanced deep learning model of true positive eloquent white matter tractography to improve preoperative evaluation of pediatric epilepsy surgery.Medical image analysis · 2026Article
- Hallmarks of primary headache: part 4 - rare headache syndromes.The journal of headache and pain · 2025Review
- A Multimodal Deep Learning Approach for White Matter Shape Prediction in Diffusion MRI Tractography.Human brain mapping · 2025Article
- The Emerging Clinical Relevance of Artificial Intelligence, Data Science, and Wearable Devices in Headache: A Narrative Review.Life (Basel, Switzerland) · 2025Review
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16 authors.
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Abstract
backgroundNew daily persistent headache (NDPH) is a rare primary headache disorder characterized by daily and persistent sudden onset headaches. Specific abnormalities in gray matter and white matter structure are associated with pain, but have not been well studied in NDPH. The objective of this work is to explore the fiber tracts and structural connectivity, which can help reveal unique gray and white matter structural abnormalities in NDPH.
methodsThe regional radiomics similarity networks were calculated from T1 weighted (T1w) MRI to depict the gray matter structure. The fiber connectivity matrices weighted by diffusion metrics like fractional anisotropy (FA), mean diffusivity (MD) and radial diffusivity (RD) were built, meanwhile the fiber tracts were segmented by anatomically-guided superficial fiber segmentation (Anat-SFSeg) method to explore the white matter structure from diffusion MRI. The considerable different neuroimaging features between NDPH and healthy controls (HC) were extracted from the connectivity and tract-based analyses. Finally, decision tree regression was used to predict the clinical scores (i.e. pain intensity) from the above neuroimaging features.
resultsT1w and diffusion MRI data were available in 51 participants after quality control: 22 patients with NDPH and 29 HCs. Significantly decreased morphological similarity was found between the right superior frontal gyrus and right hippocampus. The superficial white matter (SWM) showed significantly decreased FA in fiber tracts including the right superficial-frontal, left superficial-occipital, bilateral superficial-occipital-temporal (Sup-OT) and right superficial-temporal, meanwhile significant increased RD was found in the left Sup-OT. For the fiber connectivity, NDPH showed significantly decreased FA in the bilateral basal ganglion and temporal lobe, increased MD in the right frontal lobe, and increased RD in the right frontal lobe and left temporal-occipital lobe. Clinical scores could be predicted dominantly by the above significantly different neuroimaging features through decision tree regression.
conclusionsOur research indicates the structural abnormalities of SWM and the neural pathways projected between regions like right hippocampus and left caudate nucleus, along with morphological similarity changes between the right superior frontal gyrus and right hippocampus, constitute the pathological features of NDPH. The decision tree regression demonstrates correlations between these structural changes and clinical scores.
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