Evidence map›Paper›PMID 39496886›Full record

ArticleClinical oral investigations2024

Relationship between bone union and degree of bone marrow fibrosis at resection margins of advanced mandibular ORN.

Hiroaki Ohori, Eiji Iwata, Chihiro Ichikawa, Manabu Shigeoka, Yoshiaki Tadokoro, Daisuke Takeda, Junya Kusumoto, Takumi Hasegawa, Masaya Akashi

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Article in Clinical oral investigations, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Hiroaki OhoriDepartment of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Eiji IwataDepartment of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, Kobe, Japan. eiwata@med.kobe-u.ac.jp.
Chihiro IchikawaDepartment of Pathology, Kakogawa Central City Hospital, Kakogawa, Japan.
Manabu ShigeokaDepartment of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Yoshiaki TadokoroDepartment of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Daisuke TakedaDepartment of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Junya KusumotoDepartment of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Takumi HasegawaDepartment of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Masaya AkashiDepartment of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe pathological evaluation of cancellous bone at resection margins of mandibular osteoradionecrosis (ORN) has not been well elucidated. Here, we developed a unique classification system for evaluating the degree of bone marrow fibrosis, one of most common pathological features, in patients with mandibular ORN, based on which we investigated its relationship with treatment outcome.

methodsThis study included 15 patients who underwent mandibulectomy and free fibula osteocutaneous flap reconstruction. The extent of mandibulectomy was determined, with safety margins of approximately 10 mm from the apparent osteolytic areas on preoperative computed tomography image. Special staining was performed on thin sections from center of the osteolytic areas (medial area) and bilateral resection margins, and the degree of bone marrow fibrosis was evaluated and investigated its relationship with presence of bone union as a treatment outcome.

resultsThe degree of bone marrow fibrosis of medial area was significantly higher than those of resection margins. Although most resection margins had collagen fibers which indicate severe fibrosis, all transferred fibula flaps achieved bone union.

conclusionWhen mandibulectomy is performed with safety margins of approximately 10 mm from the apparent osteolytic areas, all transferred fibula flaps achieved bone union regardless of the degree of bone marrow fibrosis at resection margin. In other words, the association between severe bone marrow fibrosis at resection margins and treatment outcome was not seen. CLINICAL RELEVANCE: Setting safety margins of approximately 10 mm may achieve bone union, but further study is needed.

Indexed as

Mandibular OsteotomyMargins of ExcisionOsteoradionecrosisAgedBone MarrowFemaleFibrosisFibulaFree Tissue FlapsHumansMaleMandibleMandibular DiseasesMiddle AgedRetrospective StudiesTomography, X-Ray ComputedBone marrow fibrosisBone unionCollagen fibersOsteoradionecrosisTransferred fibula flap

Identifiers

PMID39496886
PMCPMC11534885

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