Evidence map›Paper›PMID 39496820›Full record

ArticleVirchows Archiv : an international journal of pathology2025

Bronchial salivary gland-type mucinous adenocarcinoma harboring a GNAS mutation: a novel lung cancer entity? A case report.

Cuimin Chen, Huanwen Wu, Weihua Yin, Xiaoxin Shi, Yang Zhao

Erratum issuedAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Cuimin ChenDepartment of Pathology, Shenzhen Hospital of Peking University, Shenzhen, 518036, China.
Huanwen WuDepartment of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing, 100730, China. wuhuanwen10700@pumch.cn.
Weihua YinDepartment of Pathology, Shenzhen Hospital of Peking University, Shenzhen, 518036, China.
Xiaoxin ShiDepartment of Pathology, Shenzhen Hospital of Peking University, Shenzhen, 518036, China.
Yang ZhaoDepartment of Pathology, Shenzhen Hospital of Peking University, Shenzhen, 518036, China. nongfu168@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a case of a 65-year-old man with a 1.0-cm mass in the left main bronchus, exhibiting overlapping morphological, immunohistochemical, and genetic features with both pancreatic intraductal papillary mucinous neoplasm (IPMN) with associated invasive carcinoma and salivary gland IPMN. Based on its close proximity to the bronchial submucosal glands and the expression of NKX3.1 (an established immunohistochemical marker for mucinous acinar cells of the minor salivary glands), we propose that the tumor originates from the mucinous acinar cells of the bronchial salivary gland. Therefore, we suggest naming it bronchial salivary gland-type mucinous adenocarcinoma. Interestingly, a GNAS mutation, known as a highly specific marker for pancreatic IPMN, was detected by next-generation sequencing in our case. We believe that this tumor may represent a novel lung cancer entity.

Indexed as

Adenocarcinoma, MucinousBiomarkers, TumorBronchial NeoplasmsChromograninsGTP-Binding Protein alpha Subunits, GsLung NeoplasmsMutationAgedHumansMaleBiomarkers, TumorChromograninsGNAS protein, humanGTP-Binding Protein alpha Subunits, GsBronchial salivary gland-type mucinous adenocarcinomaCase reportGNAS mutation

Identifiers

PMID39496820
PMCPMC12213937

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.