Evidence map›Paper›PMID 39496695›Full record

ArticleScientific reports2024

Association between neutrophil-percentage-to-albumin ratio (NPAR) and metabolic syndrome risk: insights from a large US population-based study.

Wei Ji, Hongwei Li, Yue Qi, Wenshuo Zhou, Yu Chang, Dongsheng Xu, Yuxi Wei

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PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Association of Neutrophil Percentage-to-Albumin Ratio (NPAR) With Pathological Features and Long-Term Prognosis in Diabetic Kidney Disease: A Cohort Study.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wei Ji *The First Hospital of Jilin University, No. 1 Xinmin Street, Changchun, 130012, China.
Hongwei Li *The First Hospital of Jilin University, No. 1 Xinmin Street, Changchun, 130012, China.
Yue QiThe First Hospital of Jilin University, No. 1 Xinmin Street, Changchun, 130012, China.
Wenshuo ZhouThe First Hospital of Jilin University, No. 1 Xinmin Street, Changchun, 130012, China.
Yu ChangThe First Hospital of Jilin University, No. 1 Xinmin Street, Changchun, 130012, China.
Dongsheng XuThe First Hospital of Jilin University, No. 1 Xinmin Street, Changchun, 130012, China. xudongs@jlu.edu.cn.
Yuxi WeiPharmacy Department of Medical Security Center of PLA General Hospital, Beijing, China. 13911208608@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metabolic syndrome (MetS) is a cluster of conditions that increase the risk of cardiovascular disease and diabetes. This study aimed to investigate the association between Neutrophil-Percentage-to-Albumin Ratio (NPAR) and MetS in a large, nationally representative US population. We analyzed data from 28,178 participants in the National Health and Nutrition Examination Survey (NHANES) 2005-2018. Logistic regression models were used to evaluate the association between NPAR and MetS. Restricted cubic spline (RCS) models were employed to assess the dose-response relationship. Mediation analyses were conducted to explore potential mediating effects of serum uric acid and triglyceride-glucose (TyG) index. After adjusting for confounders, participants in the highest NPAR quartile had a 14% higher risk of MetS compared to those in the lowest quartile (OR 1.14, 95%CI 1.03-1.27, P = 0.010). RCS models revealed a monotonic increasing trend between NPAR and MetS risk (P for overall association = 0.002). Mediation analyses showed that serum uric acid and TyG index mediated 14.93% and 29.45% of the total effect of NPAR on MetS, respectively. Subgroup analyses indicated that the positive association between NPAR and MetS was more pronounced in Mexican Americans, individuals aged 20-65 years, those with lower income, males, current smokers, and moderate drinkers. Higher NPAR is associated with increased risk of MetS in the US adult population. This association is partially mediated by serum uric acid and TyG index. These findings suggest that NPAR may serve as a novel biomarker for MetS risk assessment and provide insights into potential mechanisms linking inflammation and metabolic disorders.

Indexed as

Metabolic SyndromeNeutrophilsNutrition SurveysAdultAgedBiomarkersBlood GlucoseFemaleHumansMaleMiddle AgedRisk FactorsSerum AlbuminTriglyceridesUnited StatesUric AcidBiomarkersBlood GlucoseSerum AlbuminTriglyceridesUric AcidMediation analysis3Metabolic syndrome (MetS)2Neutrophil-percentage-to-albumin ratio (NPAR)1NHANES5Triglyceride-glucose (TyG) index4

Identifiers

PMID39496695
PMCPMC11535182

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.