ArticleNPJ Parkinson's disease2024
The effect of pallidal stimulation on sleep outcomes and related brain connectometries in Parkinson's disease.
Article in NPJ Parkinson's disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
5 citing papers in PubMed.
- Sleep circuit modulation: from animal models to human translation.Brain : a journal of neurology · 2026Review
- Nonmotor Symptoms in Parkinson's Disease: Neurophysiology Biomarkers and Neuromodulation Approaches.Stereotactic and functional neurosurgery · 2026Review
- Functional and Structural Connectivity Correlates of Axial Symptom Outcomes After Pallidal Deep Brain Stimulation in Parkinson's Disease.Brain sciences · 2025Article
- Brain signature of sleep quality.Sleep · 2025Article
- Advancements in invasive and non-invasive neuromodulation for Parkinson's disease: current findings and future directions.NPJ Parkinson's disease · 2025Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Sleep difficulties affect up to 98% of Parkinson's disease (PD) patients and are often not well treated. How globus pallidus internus (GPi)-DBS could help is less understood. We retrospectively analyzed sleep outcomes in 32 PD patients after GPi-DBS with a two-year follow-up. We observed high heterogeneity in sleep response to pallidal stimulation: 16 patients showed clinically meaningful improvement, 9 had minor changes, and 7 experienced worsened sleep quality, with no overall significant change on the Parkinson's Disease Sleep Scale-2 (P = 0.19). Further analysis revealed that stimulation of the left sensorimotor GPi was significantly associated with sleep improvement. Fiber tracts from the left sensorimotor GPi to the bilateral sensorimotor cortex, right GPi, brainstem, and bilateral cerebellum were linked to better sleep, while projections to the left hippocampus correlated with worsened sleep. These findings may guide personalized GPi-DBS lead placement to optimize sleep outcomes in PD.
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Registered trials
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