ArticleInfluenza and other respiratory viruses2024
Severe Neurological Complications With Influenza in Vietnamese Children.
Article in Influenza and other respiratory viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Influenza-associated neurological complications in pediatric patients: clinical characteristics, outcomes, and the neuroinfluenza severity score in the multicenter TURK-INF study.European journal of pediatrics · 2026Article
- Decoding the lung-brain axis in influenza: from pulmonary infection to central nervous system injury.Journal of neuroinflammation · 2026Review
- Clinical Characteristics Associated with Mortality in Children with Critically Ill Influenza B in the Pediatric Intensive Care Unit.Infection and drug resistance · 2026Article
- Clinical features of a fatal case of acute encephalitis associated with a novel influenza H3N2 recombinant virus possessing human-origin H7N9 internal genes: a descriptive study.Emerging microbes & infections · 2025Article
- Influenza-Related Encephalopathy in Children: Epidemiology and Literature Review from a Tertiary Hospital in Northern Italy (Winter 2023-2024).Pathogens (Basel, Switzerland) · 2025Review
- Viral-associated septic shock in pediatric pneumonia: a retrospective analysis of pathogen-specific risks and comparative clinical features with bacterial sepsis.Frontiers in pediatrics · 2025Article
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundInfluenza is a common contagious respiratory virus that primarily causes respiratory tract infections. Neurological complications associated with influenza have also been reported, mainly in pediatric populations, and may be fatal.
methodsA descriptive study evaluated pediatric patients who were diagnosed with severe influenza-associated neurological complications at the Tropical Pediatrics Center-Vietnam National Children's Hospital from October 2022 to February 2024.
resultsIn this study involving 20 patients, 80% of children were under 5 years old; 70% of patients had a history of good health. All patients had not received an influenza vaccination within 12 months. The median time from onset to neurological symptoms was 1 day. The most common neurological complication was encephalitis (16/20 patients) with symptoms included altered consciousness and seizures. Most patients had elevated levels of ALT (60%), AST (90%), LDH (94%), and ferritin (69%) in serum. The imaging of brain damage on MRI and CT scans varied in patterns and locations. There was no difference in the timing of methylprednisolone treatment within and after 48 h. The mortality rate was 20%, with 45% of patients experiencing severe sequelae.
conclusionsIANCs are severe with damage to both white matter and central gray matter and can occur in healthy children, emphasizing the importance of vaccination to reduce the risk.
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