Evidence map›Paper›PMID 39496339›Full record

ArticleInfluenza and other respiratory viruses2024

Effectiveness of Original Monovalent and Bivalent COVID-19 Vaccines Against COVID-19-Associated Hospitalization and Severe In-Hospital Outcomes Among Adults in the United States, September 2022-August 2023.

Jennifer DeCuir, Diya Surie, Yuwei Zhu, Adam S Lauring, Manjusha Gaglani, Tresa McNeal, Shekhar Ghamande, Ithan D Peltan, Samuel M Brown, Adit A Ginde and 43 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Influenza and other respiratory viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

53 authors.

Jennifer DeCuirNational Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, USA.
Diya SurieNational Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, USA.ORCID 0000-0003-3931-1423
Yuwei ZhuDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Adam S LauringDepartments of Internal Medicine and Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.
Manjusha GaglaniBaylor College of Medicine, Baylor Scott & White Health, Temple and Dallas, Texas, Temple, Texas, USA.
Tresa McNealBaylor College of Medicine, Baylor, Scott & White Health, Temple, Texas, USA.
Shekhar GhamandeBaylor College of Medicine, Baylor, Scott & White Health, Temple, Texas, USA.
Ithan D PeltanDepartment of Pulmonary/Critical Care Medicine, Intermountain Medical Center, Murray, Utah and University of Utah, Salt Lake City, Utah, USA.
Samuel M BrownDepartment of Pulmonary/Critical Care Medicine, Intermountain Medical Center, Murray, Utah and University of Utah, Salt Lake City, Utah, USA.
Adit A GindeDepartment of Emergency Medicine, University of Colorado School of Medicine, Colorado, Aurora, USA.
Aimee SteinwandDepartment of Emergency Medicine, University of Colorado School of Medicine, Colorado, Aurora, USA.
Nicholas M MohrDepartments of Emergency Medicine, Anesthesia Critical Care, and Epidemiology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.ORCID 0000-0003-0497-5828
Kevin W GibbsDepartment of Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
David N HagerDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Harith AliDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Anne FroschDepartment of Emergency Medicine, Hennepin Healthcare Research Institute, Hennepin Healthcare System, Minneapolis, Minnesota, USA.
Michelle N GongDepartment of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York, USA.
Amira MohamedDepartment of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York, USA.
Nicholas J JohnsonDepartment of Emergency Medicine and Division of Pulmonary, Critical Care and Sleep Medicine, University of Washington, Seattle, Washington, USA.
Vasisht SrinivasanDepartment of Emergency Medicine, University of Washington, Seattle, Washington, USA.
Jay S SteingrubDepartment of Medicine, Baystate Medical Center, Springfield, Massachusetts, USA.
Akram KhanDepartment of Medicine, Oregon Health and Sciences University, Portland, Oregon, USA.ORCID 0000-0003-3091-632X
Laurence W BusseDepartment of Medicine, Emory University, Atlanta, Georgia, USA.
Abhijit DuggalDepartment of Medicine, Cleveland Clinic, Cleveland, Ohio, USA.
Jennifer G WilsonDepartment of Emergency Medicine, Stanford University School of Medicine, Stanford, California, USA.
Nida QadirDepartment of Medicine, University of California-Los Angeles, Los Angeles, California, USA.
Steven Y ChangDepartment of Medicine, University of California-Los Angeles, Los Angeles, California, USA.
Christopher MallowDepartment of Medicine, University of Miami, Miami, Florida, USA.
Jennie H KwonDepartment of Medicine, Washington University, St. Louis, Missouri, USA.
Matthew C ExlineDepartment of Medicine, The Ohio State University, Columbus, Ohio, USA.
Nathan I ShapiroDepartment of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Cristie ColumbusBaylor, Scott & White Health, Texas A&M University College of Medicine, Dallas, Texas, USA.
Ivana A VaughnDepartment of Public Health Sciences, Henry Ford Health, Detroit, Michigan, USA.ORCID 0000-0002-7201-0289
Mayur RameshDivision of Infectious Diseases, Henry Ford Health, Detroit, Michigan, USA.
Basmah SafdarDepartment of Emergency Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Jarrod M MosierDepartment of Emergency Medicine, University of Arizona, Tucson, Arizona, USA.
Jonathan D CaseyDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
H Keipp TalbotDepartments of Medicine and Health Policy, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Todd W RiceDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Natasha HalasaDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
James D ChappellDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Carlos G GrijalvaDepartment of Health Policy, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Adrienne BaughmanDepartment of Emergency Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Kelsey N WomackVanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Jillian P RhoadsVanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Sydney A SwanDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Cassandra JohnsonDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Nathaniel LewisNational Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, USA.ORCID 0000-0001-7088-9640
Sascha EllingtonNational Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, USA.
Fatimah S DawoodNational Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, USA.
Meredith McMorrowNational Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, USA.ORCID 0000-0001-6363-4033
Wesley H SelfVanderbilt Institute for Clinical and Translational Research and Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Investigating Respiratory Viruses in the Acutely Ill (IVY) Network

Funding

Measuring and Learning from Care Variation in SepsisR35GM151147 · NIGMS · IHC HEALTH SERVICES, INC. · PI Ithan Daniel Peltan · 2023 to 2026
$1.5M
CDC HHS 75D30122C14944NIGMS NIH HHS R35 GM151147
6 · The paper itself

Abstract

backgroundAssessments of COVID-19 vaccine effectiveness are needed to monitor the protection provided by updated vaccines against severe COVID-19. We evaluated the effectiveness of original monovalent and bivalent (ancestral strain and Omicron BA.4/5) COVID-19 vaccination against COVID-19-associated hospitalization and severe in-hospital outcomes.

methodsDuring September 8, 2022 to August 31, 2023, adults aged ≥ 18 years hospitalized with COVID-19-like illness were enrolled at 26 hospitals in 20 US states. Using a test-negative case-control design, we estimated vaccine effectiveness (VE) with multivariable logistic regression adjusted for age, sex, race/ethnicity, admission date, and geographic region.

resultsAmong 7028 patients, 2924 (41.6%) were COVID-19 case patients, and 4104 (58.4%) were control patients. Compared to unvaccinated patients, absolute VE against COVID-19-associated hospitalization was 6% (-7%-17%) for original monovalent doses only (median time since last dose [IQR] = 421 days [304-571]), 52% (39%-61%) for a bivalent dose received 7-89 days earlier, and 13% (-10%-31%) for a bivalent dose received 90-179 days earlier. Absolute VE against COVID-19-associated invasive mechanical ventilation or death was 51% (34%-63%) for original monovalent doses only, 61% (35%-77%) for a bivalent dose received 7-89 days earlier, and 50% (11%-71%) for a bivalent dose received 90-179 days earlier.

conclusionBivalent vaccination provided protection against COVID-19-associated hospitalization and severe in-hospital outcomes within 3 months of receipt, followed by a decline in protection to a level similar to that remaining from previous original monovalent vaccination by 3-6 months. These results underscore the benefit of remaining up to date with recommended COVID-19 vaccines.

Indexed as

COVID-19COVID-19 VaccinesHospitalizationSARS-CoV-2Vaccine EfficacyAdolescentAdultAgedAged, 80 and overCase-Control StudiesFemaleHumansMaleMiddle AgedUnited StatesVaccinationCOVID-19 VaccinesadultCOVID‐19COVID‐19 vaccineshospitalizationUnited States

Identifiers

PMID39496339
PMCPMC11534416

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.