Evidence map›Paper›PMID 39495936›Full record

ArticleDevelopment (Cambridge, England)2024

Retinal ganglion cell-derived semaphorin 6A segregates starburst amacrine cell dendritic scaffolds to organize the mouse inner retina.

Rebecca E James, Natalie R Hamilton, Lola Nicole Huffman, Matthew P Brown, Victoria N Neckles, R Jeroen Pasterkamp, Loyal A Goff, Alex L Kolodkin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Development (Cambridge, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rebecca E JamesThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins Kavli Neuroscience Discovery Institute, The Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.
Natalie R HamiltonThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins Kavli Neuroscience Discovery Institute, The Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.
Lola Nicole HuffmanThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins Kavli Neuroscience Discovery Institute, The Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.
Matthew P BrownThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins Kavli Neuroscience Discovery Institute, The Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.
Victoria N NecklesThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins Kavli Neuroscience Discovery Institute, The Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.
R Jeroen PasterkampDepartment of Translational Neuroscience, University Medical Center Utrecht Brain Center, Utrecht University, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands.
Loyal A GoffThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins Kavli Neuroscience Discovery Institute, The Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.
Alex L KolodkinThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins Kavli Neuroscience Discovery Institute, The Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.ORCID 0000-0001-7562-5513

Funding

Uncover the Pathogenesis of Brain Arteriovenous MalformationR01NS027713 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SU, HUA · 1990 to 2023
$8.6M
Visual Science Training ProgramT32EY007143 · NEI · JOHNS HOPKINS UNIVERSITY · PI Laura Ensign, JEREMY NATHANS · 1995 to 2026
$6.2M
Training Program in NeuroscienceT32NS091018 · NINDS · JOHNS HOPKINS UNIVERSITY · PI JAMES J KNIERIM, Daniel Hans O'Connor · 2015 to 2026
$4.1M
Identification of enteric Juvenile Protective Factors and their role in stimulating neurogenesis in the adult and ageing Enteric Nervous SystemR01AG066768 · NIA · JOHNS HOPKINS UNIVERSITY · PI GOFF, LOYAL ANDREW, KULKARNI, SUBHASH · 2021 to 2025
$3.3M
Molecular and functional regeneration of the accessory optic pathwayR01EY027713 · NEI · JOHNS HOPKINS UNIVERSITY · PI HUBERMAN, ANDREW D, KOLODKIN, ALEX L · 2017 to 2020
$2.4M
Molecular mechanisms underlying direction-selective circuit assembly and function in the mouse visual systemR01EY032095 · NEI · JOHNS HOPKINS UNIVERSITY · PI KOLODKIN, ALEX L · 2021 to 2025
$2.3M
Aging dependent transformation of oligodendrocyte precursor cellsR01AG072305 · NIA · JOHNS HOPKINS UNIVERSITY · PI BERGLES, DWIGHT E, GOFF, LOYAL ANDREW · 2021 to 2025
$2.0M
Wiring direction-selective circuits in the mouse retinaF32EY025114 · NEI · JOHNS HOPKINS UNIVERSITY · PI JAMES, REBECCA ELLEN · 2015 to 2017
$112k
BIOBEHAVIORAL STUDY OF MUSCLE CONTRACTION HEADACHER01NS025114 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT · PI HATCH, JOHN P · 1987 to 1989
–
Howard Hughes Medical InstituteNederlandse Hersenbank ENW-VICINEI NIH HHS F32 EY025114NEI NIH HHS R01 EY027713NEI NIH HHS R01 EY032095NEI NIH HHS T32 EY007143Netherlands Organization for Scientific Research ENW-VICINIA NIH HHS R01 AG066768NIA NIH HHS R01 AG072305NIH HHS EY027713NINDS NIH HHS 5T32EY007143-20NINDS NIH HHS AG066768NINDS NIH HHS AG072305NINDS NIH HHS EY027713NINDS NIH HHS EY032095NINDS NIH HHS F32EY025114NINDS NIH HHS T32 NS091018
6 · The paper itself

Abstract

To form functional circuits, neurons must settle in their appropriate cellular locations, and then project and elaborate neurites to contact their target synaptic neuropils. Laminar organization within the vertebrate retinal inner plexiform layer (IPL) facilitates pre- and postsynaptic neurite targeting, yet the precise mechanisms underlying establishment of functional IPL subdomains are not well understood. Here, we explore mechanisms defining the compartmentalization of OFF and ON neurites generally, and OFF and ON direction-selective neurites specifically, within the developing mouse IPL. We show that semaphorin 6A (Sema6A), a repulsive axon guidance cue, is required for delineation of OFF versus ON circuits within the IPL: in the Sema6a null IPL, the boundary between OFF and ON domains is blurred. Furthermore, Sema6A expressed by retinal ganglion cells (RGCs) directs laminar segregation of OFF and ON starburst amacrine cell dendritic scaffolds, which themselves serve as a substrate upon which other retinal neurites elaborate. These results demonstrate that RGCs, the first type of neuron born within the retina, play an active role in functional specialization of the IPL.

Indexed as

Amacrine CellsDendritesRetinaRetinal Ganglion CellsSemaphorinsAnimalsMiceMice, Inbred C57BLMice, KnockoutNeuritesSema6a protein, mouseSemaphorinsDirection selectivityRetinal patterningSema6AStarburst amacrine cells

Identifiers

PMID39495936
PMCPMC11634039

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.