Evidence map›Paper›PMID 39495923›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

A conserved juxtamembrane motif in plant NFR5 receptors is essential for root nodule symbiosis.

Simon Boje Hansen, Thi Bich Luu, Kira Gysel, Damiano Lironi, Christina Krönauer, Henriette Rübsam, Ingeborg Bitsch Jensen, Magdalini Tsitsikli, Thea Gramkov Birkefeldt, Alen Trgovcevic and 3 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Structure-informed engineering of plant-microbe interactions.The Plant journal : for cell and molecular biology · 2026
    Review
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Simon Boje HansenDepartment of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark.ORCID 0000-0002-0843-3922
Thi Bich LuuDepartment of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark.ORCID 0000-0001-8148-6927
Kira GyselDepartment of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark.ORCID 0000-0003-4245-9998
Damiano LironiDepartment of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark.ORCID 0000-0002-6293-4832
Christina KrönauerDepartment of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark.ORCID 0000-0002-3172-5149
Henriette RübsamDepartment of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark.ORCID 0000-0003-4667-5700
Ingeborg Bitsch JensenDepartment of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark.ORCID 0009-0001-7136-3859
Magdalini TsitsikliDepartment of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark.ORCID 0009-0008-8753-529X
Thea Gramkov BirkefeldtDepartment of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark.
Alen TrgovcevicDepartment of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark.ORCID 0000-0001-7709-6803
Jens StougaardDepartment of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark.ORCID 0000-0002-9312-2685
Simona RadutoiuDepartment of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark.ORCID 0000-0002-8841-1415
Kasper Røjkjær AndersenDepartment of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark.ORCID 0000-0002-4415-8067

Funding

Bill and Melinda Gates Foundation (GF) INV- 57461Danish Council for Independent Research 9040-00175B and 3103-00137B
6 · The paper itself

Abstract

Establishment of root nodule symbiosis is initiated by the perception of bacterial Nod factor ligands by the plant LysM receptor kinases NFR1 and NFR5. Receptor signaling initiating the symbiotic pathway depends on the kinase activity of NFR1, while the signaling mechanism of the catalytically inactive NFR5 pseudokinase is unknown. Here, we present the crystal structure of the signaling-competent

Indexed as

Amino Acid MotifsLotusPlant ProteinsRoot Nodules, PlantSymbiosisAmino Acid SequenceSignal TransductionPlant Proteinskinases and pseudokinasesNod factor receptorsplant–microbe interactionsreceptor signalingroot nodule symbiosis

Identifiers

PMID39495923
PMCPMC11572979

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.