Optimization of breeding program design through stochastic simulation with evolutionary algorithms.

The effective planning and allocation of resources in modern breeding programs is a complex task. Breeding program design and operational management have a major impact on the success of a breeding program and changing parameters such as the number of selected/phenotyped/genotyped individuals in the breeding program will impact genetic gain, genetic diversity, and costs. As a result, careful assessment and balancing of design parameters is crucial, taking into account the trade-offs between different breeding goals and associated costs. In a previous study, we optimized the resource allocation strategy in a dairy cattle breeding scheme via the combination of stochastic simulations and kernel regression, aiming to maximize a target function containing genetic gain and the inbreeding rate under a given budget. However, the high number of simulations required when using the proposed kernel regression method to optimize a breeding program with many parameters weakens the effectiveness of such a method. In this work, we are proposing an optimization framework that builds on the concepts of kernel regression but additionally makes use of an evolutionary algorithm to allow for a more effective and general optimization. The key idea is to consider a set of potential parameter settings of the breeding program, evaluate their performance based on stochastic simulations, and use these outputs to derive new parameter settings to test in an iterative procedure. The evolutionary algorithm was implemented in a Snakemake workflow management system to allow for efficient scaling on large distributed computing platforms. The algorithm achieved stabilization around the same optimum with a massively reduced number of simulations. Thereby, the incorporation of class variables and accounting for a higher number of parameters in the optimization framework leads to substantially reduced computing time and better scaling for the desired optimization of a breeding program.