Evidence map›Paper›PMID 39495478›Full record

ArticleJournal of nephrology2025

Clinical characteristics and outcomes of kidney transplantation in autosomal dominant polycystic kidney disease patients.

Jin Hyeog Lee, Jiyeon Myung, Sujin Gang, Hyun Jin Ryu, Nam Joon Yi, Jaeseok Yang

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Journal of nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jin Hyeog LeeDivision of Nephrology, Department of Internal Medicine, College of Medicine, Yonsei University, Seoul, Republic of Korea.
Jiyeon MyungDivision of Nephrology, Department of Internal Medicine, College of Medicine, Yonsei University, Seoul, Republic of Korea.
Sujin GangDepartment of Surgery, Seoul National University Hospital, Seoul, Republic of Korea.
Hyun Jin RyuDepartment of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Nam Joon YiDepartment of Surgery, Seoul National University Hospital, Seoul, Republic of Korea.
Jaeseok YangDivision of Nephrology, Department of Internal Medicine, College of Medicine, Yonsei University, Seoul, Republic of Korea. jcyjs@yuhs.ac.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundKidney transplantation (KT) is the best kidney replacement treatment for autosomal dominant polycystic kidney disease (ADPKD). We aimed to investigate the clinical characteristics and outcomes of KT in ADPKD patients compared to those in non-ADPKD patients.

methodsWe retrospectively analyzed KT recipients in two Korean transplantation centers from 2005 to 2020. Propensity score-matching and Cox regression analysis were used to assess the clinical outcomes of ADPKD compared to non-ADPKD and identify prognostic factors influencing outcomes in ADPKD.

resultsAmong a total of 4452 KT patients, 189 (4.2%) were ADPKD patients. Median age at transplantation was 53.0 and 47.0 in ADPKD and non-ADPKD patients, respectively. In both groups, living-donor KT was more common than deceased-donor KT. The ADPKD group had a 4.09-fold higher risk of post-transplant diabetes mellitus and a 1.65-fold higher risk of post-transplant infection compared to the non-ADPKD group; however, subjects with ADPKD had similar risk of rejection, graft failure, and mortality. In the ADPKD group, kidney volume decreased after KT, irrespective of kidney volume status (Mayo classification), while the size of hepatic cysts increased. Neither kidney volume nor nephrectomy of native kidneys were associated with risk of infection, graft failure, or mortality in the ADPKD group.

conclusionsADPKD patients have a higher risk of post-transplant diabetes mellitus and infection than non-ADPKD patients, with no significant impact of kidney volume or nephrectomy on post-transplant outcomes.

Indexed as

Kidney TransplantationPolycystic Kidney, Autosomal DominantPostoperative ComplicationsAdultFemaleGraft RejectionGraft SurvivalHumansKidneyMaleMiddle AgedRepublic of KoreaRetrospective StudiesRisk FactorsTreatment OutcomeAutosomal dominant polycystic kidney diseaseKidney transplantationPost-transplant diabetes mellitusPost-transplant infection

Identifiers

PMID39495478

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.