Evidence map›Paper›PMID 39495434›Full record

ArticleBreast cancer research and treatment2025

Racial disparities in presenting stage and surgical management among octogenarians with breast cancer: a national cancer database analysis.

Amulya Vadlakonda, Nikhil L Chervu, Giselle Porter, Sara Sakowitz, Hanjoo Lee, Peyman Benharash, Nimmi S Kapoor

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Article in Breast cancer research and treatment, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Amulya VadlakondaDepartment of Surgery, University of California, 15503 Ventura Blvd, Ste. 150, Encino, Los Angeles, CA, 91436, USA.
Nikhil L ChervuDepartment of Surgery, University of California, 15503 Ventura Blvd, Ste. 150, Encino, Los Angeles, CA, 91436, USA.
Giselle PorterDepartment of Surgery, University of California, 15503 Ventura Blvd, Ste. 150, Encino, Los Angeles, CA, 91436, USA.
Sara SakowitzDepartment of Surgery, University of California, 15503 Ventura Blvd, Ste. 150, Encino, Los Angeles, CA, 91436, USA.
Hanjoo LeeDepartment of Surgery, Harbor-UCLA Medical Center, Torrance, CA, USA.
Peyman BenharashDepartment of Surgery, University of California, 15503 Ventura Blvd, Ste. 150, Encino, Los Angeles, CA, 91436, USA.
Nimmi S KapoorDepartment of Surgery, University of California, 15503 Ventura Blvd, Ste. 150, Encino, Los Angeles, CA, 91436, USA. NSKapoor@mednet.ucla.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAs the US faces a diverse aging population, racial disparities in breast cancer outcomes among elderly patients remain poorly understood. We evaluate the association of race with presenting stage, treatment, and survival of invasive breast cancer among octogenarians.

methodsWomen (≥ 80 years) with invasive breast cancer were identified in 2004-2020 NCDB. To facilitate comparison, only non-Hispanic Black and non-Hispanic White patients were included; patients of Hispanic ethnicity were excluded. Demographics, tumor characteristics, and treatments were assessed by race. Overall survival was compared using the logrank test. Multivariable logistic and Cox proportional hazard regression models were developed to evaluate the independent association of race with outcomes of interest.

resultsOf 222,897 patients, 19,059 (8.6%) were Black. Most patients had stage I ER + HER2- invasive ductal carcinoma. Black patients more frequently had greater comorbidities, low income and education, and advanced stage (p < 0.001 each; ref: White). Following adjustment, Black women had increased likelihood of Stage III/IV over time, as well as increased odds of chemotherapy (AOR 1.22, 95% CI 1.15 - 1.29) and non-operative management (AOR 1.82, 95% CI 1.72 - 1.92; ref: White). Although Black patients had lower survival rates compared to White, race was not associated with 5-year mortality following adjustment for stage, receipt of surgery, and adjuvant treatments (p = 0.34).

conclusionsInferior survival among elderly Black patients appears be driven by advanced stage at presentation. While such disparities are narrowing in the present era, future work must consider upstream interventions to ensure equitable outcomes for all races.

Indexed as

Breast NeoplasmsHealthcare DisparitiesAged, 80 and overBlack or African AmericanDatabases, FactualFemaleHumansMastectomyNeoplasm StagingUnited StatesWhiteBreast cancerBreast cancer treatmentElderlyRacial disparitiesScreeningSocial determinants of health

Identifiers

PMID39495434
PMCPMC11787174

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