Evidence map›Paper›PMID 39495364›Full record

ArticleAnnals of surgical oncology2025

Prospective Assessment of VI-RADS with Muscle Invasion in Urinary Bladder Cancer and Its Implication on Re-Resection/Restaging TURBT Patients.

Sukhad Kural, Abhay Kumar Pathak, Shweta Singh, Garima Jain, Mahima Yadav, Sakshi Agarwal, Ishan Kumar, Manjari Gupta, Yashasvi Singh, Ujwal Kumar and 4 more

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Article in Annals of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Article
  4. Review
  5. Round up.Indian journal of urology : IJU : journal of the Urological Society of India
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Sukhad Kural *Department of Urology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
Abhay Kumar Pathak *DST-CIMS, Institute of Science, Banaras Hindu University, Varanasi, India.
Shweta SinghCentre for Genetic Disorders, Institute of Science, Banaras Hindu University, Varanasi, India.
Garima JainCentre for Genetic Disorders, Institute of Science, Banaras Hindu University, Varanasi, India.
Mahima YadavDepartment of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
Sakshi AgarwalDepartment of Obstetrics and Gynaecology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
Ishan KumarDepartment of Radio-Diagnosis and Imaging, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
Manjari GuptaDST-CIMS, Institute of Science, Banaras Hindu University, Varanasi, India.
Yashasvi SinghDepartment of Urology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
Ujwal KumarDepartment of Urology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
Sameer TrivediDepartment of Urology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
S N SankhwarDepartment of Urology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
Parimal DasCentre for Genetic Disorders, Institute of Science, Banaras Hindu University, Varanasi, India.
Lalit KumarDepartment of Urology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India. lalitkumarims@bhu.ac.in.

Funding

Banaras Hindu University IoE Sch-6031-B-21966
6 · The paper itself

Abstract

backgroundBladder cancer (BCa) diagnosis relies on distinguishing muscle-invasive bladder cancer (MIBC) from non-muscle-invasive bladder cancer (NMIBC) forms. Transurethral resection of the bladder tumor (TURBT) is a standard procedure for initial staging and treatment. The Vesical Imaging-Reporting and Data System (VI-RADS) enhances diagnostic accuracy for muscle invasiveness through advanced imaging techniques, potentially reducing reliance on repeat TURBT and improving patient management.

objectiveWe aimed to evaluate the role of VI-RADS in predicting muscle invasiveness in BCa and its potential to predict adverse pathology in high-risk NMIBC to avoid unnecessary repeat TURBT procedures.

methodsIn this prospective study, we included 62 patients over the age of 18 years who underwent TURBT. In a secondary phase, patients selected for restaging TURBT (re-TURBT) were included, but those with T2 tumors or low-risk NMIBC were excluded. Multiparametric magnetic resonance imaging (MRI) examinations were scored by a radiologist using the VI-RADS 5 method, while a pathologist analyzed TURBT and re-TURBT samples for accurate staging. Statistical analysis evaluated the role of VI-RADS in BCa staging.

resultsThe VI-RADS score was the only predictive factor for muscle invasion in multivariate analysis. Setting the VI-RADS score at >3 resulted in the highest sensitivity, specificity, and diagnostic accuracy, with values of 67.0%, 89.0%, and 78%, respectively. The receiver operating characteristic area under the curve score for VI-RADS for muscle invasion was 85% for stage Ta, 61% for stage T1, and 88% for stage T2, which shows the utility of VI-RADS in the predictiveness of MIBC/NMIBC.

conclusionVI-RADS is effective in stratifying BCa patients by predicting muscle invasiveness and identifying NMIBC cases that may not need repeat TURBT.

Indexed as

Neoplasm InvasivenessNeoplasm StagingUrinary Bladder NeoplasmsAdultAgedAged, 80 and overCystectomyFemaleFollow-Up StudiesHumansMagnetic Resonance ImagingMaleMiddle AgedMultiparametric Magnetic Resonance ImagingPrognosisProspective StudiesBladder cancerMultiparametric magnetic resonance imagingNMIBCTURBTVI-RADS

Identifiers

PMID39495364

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.