Evidence map›Paper›PMID 39495361›Full record

ArticleAnnals of surgical oncology2025

Tumor Spread Through Air Spaces Predicts Survival in Resected Pulmonary Lymphoepithelial Carcinoma.

Pei-Hsing Chen, Chin Chen, Chao-Wen Lu, Tzu-Pin Lu, Yi-Hsuan Lee, Min-Shu Hsieh, Hsao-Hsun Hsu, Jin-Shing Chen

Erratum issuedAbstract read
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In one paragraph

Article in Annals of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Pei-Hsing ChenInstitute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, Taiwan.
Chin ChenDepartment of Pathology, National Taiwan University Hospital, Taipei, Taiwan.
Chao-Wen LuDivision of Thoracic Surgery, Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan.
Tzu-Pin LuDivision of Thoracic Surgery, Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan.
Yi-Hsuan LeeDepartment of Pathology, National Taiwan University Hospital, Taipei, Taiwan.
Min-Shu Hsieh *Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan. mshsieh065@gmail.com.
Hsao-Hsun Hsu *Department of Surgical Oncology, National Taiwan University Cancer Center and National Taiwan University College of Medicine, Taipei City, Taiwan. ntuhsu@gmail.com.
Jin-Shing ChenDepartment of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

Funding

Ministry of Science and Technology, Taiwan Taiwan (MOST 113-2314-B-002-038-MY3)National Taiwan University Hospital MS441National Taiwan University Hospital Hsin-Chu Branch 112-HCH084
6 · The paper itself

Abstract

backgroundTumor spread through air spaces (STAS) has been recognized as a prognostic factor for several types of lung cancers. However, information regarding its clinical significance in pulmonary lymphoepithelial carcinoma is limited. Therefore, this study investigated effects of STAS on the clinical outcomes for patients with pulmonary lymphoepithelial carcinoma.

methodsThis study retrospectively reviewed 56 surgically resected pulmonary lymphoepithelial carcinomas. The study defined STAS as the presence of tumor cells within air spaces in lung parenchyma beyond the tumor edge. Artifacts were excluded. Recurrence-free survival (RFS) was analyzed using the log-rank test and Cox proportional hazards model.

resultsIn 18 patients (32.1%), STAS was observed and found to be associated with larger tumor size (>3 cm) (p = 0.009), higher pathologic stage (p = 0.026), and tumor necrosis (p = 0.046). Patients with STAS had a significantly lower 5-year RFS rate (p = 0.025). Multivariate analysis showed that STAS was an independent predictor of worse RFS (hazard ratio, 3.395; p = 0.038). Patients with STAS had a significantly increased risk of locoregional recurrence (p = 0.049).

conclusionsThe study findings suggest that STAS is an independent predictor of poor RFS. Based on these findings, a new three-tier grading system based on the patterns of tumor border and STAS was proposed for effective prediction of 5-year RFS in pulmonary lymphoepithelial carcinoma.

Indexed as

Carcinoma, Squamous CellLung NeoplasmsNeoplasm Recurrence, LocalAdultAgedAged, 80 and overFemaleFollow-Up StudiesHumansMaleMiddle AgedNeoplasm InvasivenessNeoplasm StagingPrognosisRetrospective StudiesSurvival RatePrognosisPulmonary lymphoepithelial carcinomaRecurrence free survivalSpread through air spaces

Identifiers

PMID39495361

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.