Evidence map›Paper›PMID 39495350›Full record

ArticleMolecular biology reports2024

Clinical significance and potential mechanism of hsa_circ_0006892 in acute respiratory distress syndrome complicated with pulmonary fibrosis.

Shuping Zhang, Lingbo Rong, Guangwen Long, Feihong Huang, Qian Zhang, Xiulin Yang, Hongpeng Sun, Chunling Ji, Rui-Hai Ye

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular biology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shuping Zhang *Department of Dermatology, Postdoctoral Station of Clinical Medicine, The Third Xiangya Hospital of Central South University, Changsha, Hunan, 410013, China.
Lingbo Rong *Wuhan University TaiKang Medical School (School of Basic Medical Sciences), Wuhan, Hubei Province, 430071, People's Republic of China.
Guangwen LongDepartment of Emergency, Guizhou Provincial People's Hospital, No. 83, Zhongshan East Road, Guiyang, Guizhou, 550002, China. Longguangwen7510@163.com.
Feihong HuangDepartment of Emergency, Guizhou Provincial People's Hospital, No. 83, Zhongshan East Road, Guiyang, Guizhou, 550002, China.
Qian ZhangDepartment of Emergency, Guizhou Provincial People's Hospital, No. 83, Zhongshan East Road, Guiyang, Guizhou, 550002, China.
Xiulin YangDepartment of Emergency, Guizhou Provincial People's Hospital, No. 83, Zhongshan East Road, Guiyang, Guizhou, 550002, China.
Hongpeng SunDepartment of Emergency, Guizhou Provincial People's Hospital, No. 83, Zhongshan East Road, Guiyang, Guizhou, 550002, China.
Chunling JiDepartment of Emergency, Guizhou Provincial People's Hospital, No. 83, Zhongshan East Road, Guiyang, Guizhou, 550002, China.
Rui-Hai YeDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Zhejiang Chinese Medical University, No. 54, Youdian Road, Shangcheng District, Hangzhou, Zhejiang, 310000, China. Yeruihai24@163.com.

Funding

China Postdoctoral Science Foundation funded project 2022M713537Zhejiang Provincial Administration of Traditional Chinese Medicine Plan Project 2022ZB146
6 · The paper itself

Abstract

backgroundAcute respiratory distress syndrome (ARDS) is a serious acute lung injury, and can develop into pulmonary fibrosis (PLF). Circular RNAs (circRNAs) regulatory network in ARDS is important. The study explored the role of hsa_circ_0006892 in the occurrence of ARDS and the development of PLF.

methodsHsa_circ_0006892 levels were verified in serum samples of 203 ARDS patients with or without PLF, and the diagnostic value was evaluated through ROC. Cox regression analysis was performed to identify PLF-related factors. The downstream target genes were predicted online. The function and pathway of key genes were annotated through GO and KEGG pathway analysis. Protein-protein interaction (PPI) analysis was performed for the examination of protein interactions.

resultsqRT-PCR determined the downregulation of hsa_circ_0006892 in the serum of both ARDS and PLF patients. Hsa_circ_0006892 can differentiate ARDS from controls, and independently related to the development of PLF. Nine targeted related miRNAs were integrated with dysregulated miRNAs from GSE27430 dataset. Clinically, miR-486-3p was the only miRNA that was significantly different in both ARDS and PLF groups, and was determined to be the target of hsa_circ_0006892. 180 target genes of miR-486-3p were predicted, which were integrated with ARDS and PLF-related GSE84439 and GSE38958 datasets. Go and KEGG pathway analysis identified Ras signaling pathway as the most commonly enriched pathway in the overlapped genes.

conclusionsThe present results identified the differentially expressed hsa_circ_0006892 in ARDS and PLF, and suggested a possible molecular mechanism of hsa_circ_0006892/miR-486-3p axis.

Indexed as

MicroRNAsProtein Interaction MapsPulmonary FibrosisRespiratory Distress SyndromeRNA, CircularAdultAgedClinical RelevanceFemaleGene Expression ProfilingGene Regulatory NetworksHumansMaleMiddle AgedMicroRNAsMIRN486 microRNA, humanRNA, CircularARDSBioinformatics analysishsa_circ_0006892/miR-486-3p axisPulmonary fibrosis

Identifiers

PMID39495350

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.