Evidence map›Paper›PMID 39495121›Full record

ArticleeLife2024

Reassessing the substrate specificities of the major

Lina Antenucci, Salla Virtanen, Chandan Thapa, Minne Jartti, Ilona Pitkänen, Helena Tossavainen, Perttu Permi

Abstract read
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review of the Composition and Antimicrobial Roles of Extracts of Vine Tea (Ampelopsis grossedentata).Medical science monitor : international medical journal of experimental and clinical research · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lina AntenucciDepartment of Biological and Environmental Science, Nanoscience Center, University of Jyvaskyla, Jyväskylä, Finland.ORCID https://orcid.org/0000-0003-1201-9342
Salla VirtanenInstitute of Biotechnology, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.
Chandan ThapaDepartment of Biological and Environmental Science, Nanoscience Center, University of Jyvaskyla, Jyväskylä, Finland.
Minne JarttiDepartment of Biological and Environmental Science, Nanoscience Center, University of Jyvaskyla, Jyväskylä, Finland.
Ilona PitkänenDepartment of Biological and Environmental Science, Nanoscience Center, University of Jyvaskyla, Jyväskylä, Finland.
Helena TossavainenDepartment of Biological and Environmental Science, Nanoscience Center, University of Jyvaskyla, Jyväskylä, Finland.ORCID https://orcid.org/0000-0002-1609-1651
Perttu PermiDepartment of Biological and Environmental Science, Nanoscience Center, University of Jyvaskyla, Jyväskylä, Finland.ORCID https://orcid.org/0000-0002-6281-1138

Funding

Research Council of Finland 323435Research Council of Finland 362535
6 · The paper itself

Abstract

Orchestrated action of peptidoglycan (PG) synthetases and hydrolases is vital for bacterial growth and viability. Although the function of several PG synthetases and hydrolases is well understood, the function, regulation, and mechanism of action of PG hydrolases characterised as lysostaphin-like endopeptidases have remained elusive. Many of these M23 family members can hydrolyse glycyl-glycine peptide bonds and show lytic activity against

Indexed as

LysostaphinN-Acetylmuramoyl-L-alanine AmidaseStaphylococcus aureusBacterial ProteinsEndopeptidasesMagnetic Resonance SpectroscopyPeptidoglycanSubstrate SpecificityBacterial ProteinsEndopeptidasesLysostaphinLytM protein, Staphylococcus aureusN-Acetylmuramoyl-L-alanine AmidasePeptidoglycanbiochemistrychemical biologyinfectious diseaselysostaphinLytMmicrobiologyNMR spectroscopypeptidoglycan hydrolasesS. aureussubstrate specificity

Identifiers

PMID39495121
PMCPMC11534333

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.