Evidence map›Paper›PMID 39495070›Full record

ArticleThe journal of spinal cord medicine2025

Effects of withdrawal and re-application of spinal cord stimulation to restore cough.

Anthony F DiMarco, Robert T Geertman, Chong Kim, Gregory A Nemunaitis, Krzysztof E Kowalski

Abstract readCase Reports
In one paragraph

Article in The journal of spinal cord medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. An update on spinal cord injury and diaphragm neuromotor control.Expert review of respiratory medicine · 2025
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Anthony F DiMarcoDepartment of Physical Medicine and Rehabilitation, Case Western Reserve University, Cleveland, OH, USA.
Robert T GeertmanDepartment of Neurosurgery.
Chong KimDepartment of Physical Medicine and Rehabilitation, Case Western Reserve University, Cleveland, OH, USA.
Gregory A NemunaitisDepartment of Physical Medicine and Rehabilitation, Cleveland Clinic, Cleveland, OH, USA.
Krzysztof E KowalskiDepartment of Physical Medicine and Rehabilitation, Case Western Reserve University, Cleveland, OH, USA.

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024989 · NCRR · CASE WESTERN RESERVE UNIVERSITY · PI DAVIS, PAMELA B · 2007 to 2011
$53.7M
Clinical and Translational Science Collaborative of ClevelandUL1TR002548 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI MCCOMSEY, GRACE A · 2018 to 2022
$35.5M
Clinical and Translational Science Collaborative of Northern Ohio, Catalyzing Linkages to Equity in Health (CLE Health)UM1TR004528 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI GRACE A MCCOMSEY · 2023 to 2026
$32.1M
Zosuquidar trihydrochloride for acute myeloid leukemia &refractory anemiaM01RR000080 · NCRR · UNIVERSITY HOSPITALS OF CLEVELAND · PI DEARBORN, DORR GELLATLY · 1985 to 2007
$22.2M
Evaluation of Spinal Cord Stimulation Using Wire Leads to Restore an Effective CoU01NS083696 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI DIMARCO, ANTHONY F. · 2013 to 2018
$2.7M
NCATS NIH HHS UL1 TR002548NCATS NIH HHS UM1 TR004528NCRR NIH HHS M01 RR000080NCRR NIH HHS UL1 RR024989NINDS NIH HHS U01 NS083696
6 · The paper itself

Abstract

contextParalysis of the expiratory muscles in cervical and high thoracic spinal cord injury (SCI) results in an impaired ability to clear airway secretions effectively and increases the risk of atelectasis and respiratory tract infections (RTI). Spinal cord stimulation (SCS) applied via the Cough Stimulation System (CSS) has been shown to restore an effective cough mechanism in subjects with SCI. In this study, we evaluated the specific impact of use of the CSS by one study participant with SCI, subsequent discontinuation of usage, and then re-institution of this modality. Airway pressure generation (P) and peak expiratory airflow rate (F) achieved with CSS and clinical assessment questionnaires were assessed.

findingsWith the CSS, this subject was able to generate P and F rates of 103 cmH CONCLUSION/CLINICAL RELEVANCE: This report demonstrates the very high degree of the clinical utility of the CSS as it had made a substantial beneficial impact on this participant's respiratory status and life quality.

Indexed as

CoughSpinal Cord InjuriesSpinal Cord StimulationHumansCoughRehabilitationSpinal cord injurySpinal cord stimulation

Identifiers

PMID39495070
PMCPMC12180311

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.