Evidence map›Paper›PMID 39494735›Full record

ArticleThe Journal of comparative neurology2024

Afferent and Efferent Connections of the Postinspiratory Complex (PiCo) Revealed by AAV and Monosynaptic Rabies Viral Tracing.

Luiz M Oliveira, Alyssa Huff, Aguan Wei, Nicole C Miranda, Ginny Wu, Xiangmin Xu, Jan-Marino Ramirez

Abstract read
In one paragraph

Article in The Journal of comparative neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Mecp2 deficiency induces dysphagia in a preclinical model of Rett syndrome.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Neural Circuit Mapping and Neurotherapy-Based Strategies.Cellular and molecular neurobiology · 2025
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Luiz M OliveiraCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, Washington, USA.ORCID 0000-0002-4071-4572
Alyssa HuffCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, Washington, USA.
Aguan WeiCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, Washington, USA.
Nicole C MirandaCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, Washington, USA.ORCID 0000-0003-0202-1027
Ginny WuDepartment of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, California, USA.
Xiangmin XuDepartment of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, California, USA.
Jan-Marino RamirezCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, Washington, USA.

Funding

Integrative Consequences of HypoxiaP01HL090554 · NHLBI · UNIVERSITY OF CHICAGO · PI PRABHAKAR, NANDURI R · 2008 to 2017
$21.4M
Cell-type-specific neural circuit connectomes in the mouse models of aging and Alzheimer's diseaseU01AG076791 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Kim Green, ERAN A MUKAMEL · 2022 to 2026
$13.6M
Mechanisms Underlying Sympathetic Activation-dependent Endothelial Cell Activation by Chronic Intermittent HypoxiaP01HL144454 · NHLBI · UNIVERSITY OF CHICAGO · PI PRABHAKAR, NANDURI R · 2019 to 2023
$12.7M
Unraveling respiratory rhythm generation in the medullary networkR01HL126523 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI Jan M. Ramirez · 2015 to 2026
$8.3M
Unraveling the dynamic mechanisms underlying opioid respiratory depressionR01HL144801 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI Jan M. Ramirez · 2019 to 2026
$5.2M
Neuroglial interactions underlying the generation of the sighR01HL151389 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI RAMIREZ, JAN M. · 2020 to 2023
$3.2M
Characterizing the neural circuitry of postinspiratory behaviors and its coordination with breathingF32HL160102 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI HUFF, ALYSSA · 2021 to 2024
$217k
NHLBI NIH HHS F32 HL160102NHLBI NIH HHS P01 HL090554NHLBI NIH HHS P01 HL144454NHLBI NIH HHS R01 HL126523NHLBI NIH HHS R01 HL144801NHLBI NIH HHS R01 HL151389NIA NIH HHS U01 AG076791NIH HHS F32 HL160102-01NIH HHS P01 HL14454NIH HHS R01 HL126523NIH HHS R01 HL144801NIH HHS R01 HL151389
6 · The paper itself

Abstract

The control of the respiratory rhythm and airway motor activity is essential for life. Accumulating evidence indicates that the postinspiratory complex (PiCo) is crucial for generating behaviors that occur during the postinspiratory phase, including expiratory laryngeal activity and swallowing. Located in the ventromedial medulla, PiCo is defined by neurons co-expressing two neurotransmitter markers (ChAT and Vglut2/Slc17a6). Here, we mapped the input-output connections of these neurons using viral tracers and intersectional viral-genetic tools. PiCo neurons were specifically targeted by focal injection of a doubly conditional Cre- and FlpO-dependent AAV8 viral marker (AAV8-Con/Fon-TVA-mCherry) into the left PiCo of adult Chat

Indexed as

DependovirusEfferent PathwaysRabies virusAfferent PathwaysAnimalsMaleMedulla OblongataMiceMice, Inbred C57BLMice, TransgenicNeuroanatomical Tract-Tracing TechniquesRespiratory CenterVesicular Glutamate Transport Protein 2Vesicular Glutamate Transport Protein 2breathingcholinergic neuronsresearch resource identifier (RRID)respiratory oscillatorrhythm

Identifiers

PMID39494735
PMCPMC12142889

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.