Evidence map›Paper›PMID 39494466›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

Very Low-Intensity Ultrasound Facilitates Glymphatic Influx and Clearance via Modulation of the TRPV4-AQP4 Pathway.

Chueh-Hung Wu, Wei-Hao Liao, Ya-Cherng Chu, Ming-Yen Hsiao, Yi Kung, Jaw-Lin Wang, Wen-Shiang Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  7. Reconstructing cerebral lymphatic clearance: an emerging target in the Alzheimer's disease therapeutic pipeline.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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  15. Advancements in Therapy for Alzheimer's Disease Based on the Cerebral Lymphatic System.Degenerative neurological and neuromuscular disease · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chueh-Hung WuDepartment of Physical Medicine and Rehabilitation, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, 100, Taiwan.ORCID 0000-0002-3979-3541
Wei-Hao LiaoDepartment of Physical Medicine and Rehabilitation, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, 100, Taiwan.
Ya-Cherng ChuDepartment of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, 106, Taiwan.
Ming-Yen HsiaoDepartment of Physical Medicine and Rehabilitation, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, 100, Taiwan.
Yi KungDepartment of Biomechatronic Engineering, National Chiayi University, Chiayi, 600, Taiwan.
Jaw-Lin WangDepartment of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, 106, Taiwan.
Wen-Shiang ChenDepartment of Physical Medicine and Rehabilitation, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, 100, Taiwan.ORCID 0000-0003-1488-5164

Funding

National Health Research Institutes BN-111-PP-03National Health Research Institutes BN-112-PP-03National Science and Technology Council 108-2321-B-002-061-MY2National Science and Technology Council 109-2314-B-002-109-MY3National Science and Technology Council 110-2314-B-002-070National Science and Technology Council 111-2314-B-002-164-MY2National Science and Technology Council 112-2314-B-002-142-MY3National Science and Technology Council 112-2321-B-002-024National Science and Technology Council 113-2314-B-002-214National Science and Technology Council 113-2321-B-002-033National Taiwan University Hospital 112-S0155National Taiwan University Hospital Hsin-Chu Branch 110-BIH009National Taiwan University Hospital Hsin-Chu Branch 111-HCH003National Taiwan University Hospital Hsin-Chu Branch NHRI-111-B01
6 · The paper itself

Abstract

Recently, the glymphatic system has been proposed as a mechanism for waste clearance from the brain parenchyma. Glymphatic dysfunction has previously been shown to be associated with several neurological diseases, including Alzheimer's disease, traumatic brain injury, and stroke. As such, it may serve as an important target for therapeutic interventions. In the present study, very low-intensity ultrasound (VLIUS) (center frequency, 1 MHz; pulse repetition frequency, 1 kHz; duty factor, 1%; spatial peak temporal average intensity [I

Indexed as

Aquaporin 4Glymphatic SystemTRPV Cation ChannelsAnimalsAstrocytesBrainMaleRatsRats, Sprague-DawleyUltrasonic WavesAquaporin 4Trpv4 protein, ratTRPV Cation Channelsaquaporin‐4glymphatictransient receptor potential vanilloid‐4ultrasoundβ‐amyloid

Identifiers

PMID39494466
PMCPMC11653672

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.