Evidence map›Paper›PMID 39494127›Full record

ArticleAnimal reproduction2024

Withanolide derivatives: natural compounds with anticancer potential offer low toxicity to fertility and ovarian follicles in mice.

Gaby Judith Quispe Palomino, Homero Ygnacio Celiz, Francisco Denilson Rodrigues Gomes, Gildas Mbemya Tetaping, Marco Aurélio Schiavo Novaes, Késya Amanda Dantas Rocha, Ramon da Silva Raposo, Rebeca Magalhães Pedrosa Rocha, Ana Beatriz Graça Duarte, Otilia Deusdênia Loiola Pessoa and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animal reproduction, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Gaby Judith Quispe PalominoLaboratório de Manipulação de Oócitos e Folículos Ovarianos Pré-antrais - LAMOFOPA, Faculdade de Medicina Veterinária, Universidade Estadual do Ceará, Fortaleza, CE, Brasil.ORCID 0000-0003-2957-0536
Homero Ygnacio CelizLaboratório de Manipulação de Oócitos e Folículos Ovarianos Pré-antrais - LAMOFOPA, Faculdade de Medicina Veterinária, Universidade Estadual do Ceará, Fortaleza, CE, Brasil.ORCID 0000-0003-2490-9342
Francisco Denilson Rodrigues GomesLaboratório de Manipulação de Oócitos e Folículos Ovarianos Pré-antrais - LAMOFOPA, Faculdade de Medicina Veterinária, Universidade Estadual do Ceará, Fortaleza, CE, Brasil.ORCID 0000-0003-4636-4195
Gildas Mbemya TetapingLaboratório de Manipulação de Oócitos e Folículos Ovarianos Pré-antrais - LAMOFOPA, Faculdade de Medicina Veterinária, Universidade Estadual do Ceará, Fortaleza, CE, Brasil.ORCID 0000-0003-4455-362X
Marco Aurélio Schiavo NovaesUniversidade da Integração Internacional da Lusofonia Afro-Brasileira, Redenção, CE, Brasil.ORCID 0000-0001-9777-2530
Késya Amanda Dantas RochaLaboratório de Análise Fitoquímica de Plantas Medicinais, Universidade Federal do Ceará, Fortaleza, CE, Brasil.ORCID 0000-0001-7596-8700
Ramon da Silva RaposoCentro de Biologia Experimental, Universidade de Fortaleza, Fortaleza, CE, Brasil.ORCID 0000-0002-6374-1442
Rebeca Magalhães Pedrosa RochaUniversidade da Integração Internacional da Lusofonia Afro-Brasileira, Redenção, CE, Brasil.ORCID 0000-0002-4991-3180
Ana Beatriz Graça DuarteDepartamento de Morfologia, Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, CE, Brasil.ORCID 0000-0002-0403-4254
Otilia Deusdênia Loiola PessoaLaboratório de Análise Fitoquímica de Plantas Medicinais, Universidade Federal do Ceará, Fortaleza, CE, Brasil.ORCID 0000-0002-1617-7586
José Ricardo FigueiredoLaboratório de Manipulação de Oócitos e Folículos Ovarianos Pré-antrais - LAMOFOPA, Faculdade de Medicina Veterinária, Universidade Estadual do Ceará, Fortaleza, CE, Brasil.ORCID 0000-0002-5139-0964
Naiza Arcângela Ribeiro de SáLaboratório de Manipulação de Oócitos e Folículos Ovarianos Pré-antrais - LAMOFOPA, Faculdade de Medicina Veterinária, Universidade Estadual do Ceará, Fortaleza, CE, Brasil.ORCID 0000-0003-4745-0108
Ana Paula Ribeiro RodriguesLaboratório de Manipulação de Oócitos e Folículos Ovarianos Pré-antrais - LAMOFOPA, Faculdade de Medicina Veterinária, Universidade Estadual do Ceará, Fortaleza, CE, Brasil.ORCID 0000-0001-9786-1250

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anticancer therapy often leads to premature ovarian insufficiency (POI) and infertility due to the extreme sensitivity of the ovarian follicle reserve to the effects of chemotherapy. Withanolides are known for their cytotoxic effect on cancer cells and low cytotoxicity on non-malignant or healthy cells. Therefore, this study aimed to investigate the

Indexed as

apoptosischemotherapycytotoxicityinfertilityreproductive function

Identifiers

PMID39494127
PMCPMC11529970

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.