Evidence map›Paper›PMID 39494123›Full record

ArticleInternational journal of reproductive biomedicine2024

The effect of L-carnitine in reactive oxygen species reduction and apoptotic gene expression in mice after cyclophosphamide: An experimental study.

Majid Almasi, Golnaz Shafiei, Hossein Nikzad, Mohammad Karimian, Ghazaleh Moshkdanian

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of reproductive biomedicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Visible light, oxidative stress, and reproduction: The protective role of melatonin.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026
    Review
  2. Preparation ofLife (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Majid AlmasiGametogenesis Research Center, Kashan University of Medical Sciences, Kashan, Iran.
Golnaz ShafieiAnatomical Sciences Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran.
Hossein NikzadGametogenesis Research Center, Kashan University of Medical Sciences, Kashan, Iran.
Mohammad KarimianDepartment of Molecular and Cell Biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Iran.
Ghazaleh MoshkdanianGametogenesis Research Center, Kashan University of Medical Sciences, Kashan, Iran.ORCID https://orcid.org/0000-0002-5409-9267

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Cyclophosphamide (CP), a utilized anticancer drug, is known to cause infertility in women. However, L-carnitine (LC), an antioxidant, has been shown to offer protective benefits against infertility. Objective: This study aimed to evaluate the levels of reactive oxygen species (ROS) and apoptotic gene expression in mice treated with CP and LC. Materials and Methods: 24 NMRI female mice (6-8 wk, 30 Results: Data revealed that LC in the LC+CP group significantly increased Conclusion: Findings suggest that LC can scavenge the ROS caused by CP and modulate the apoptotic pathway via downregulating the

Indexed as

ApoptosisCarnitineCyclophosphamideGenesReactive oxygen species.

Identifiers

PMID39494123
PMCPMC11528291

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.