ReviewHeart rhythm O22024
Considerations regarding safety with pulsed field ablation for atrial fibrillation.
Review in Heart rhythm O2, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pulsed field ablation and the risk of hemolysis-driven acute kidney injury: a systematic review and meta-analysis.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026Pooled it
- Microbubble and thermal profile of an eight-spline pulsed field ablation system in a pre-clinical model.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026Review
- Temperature as a "hidden dose" in pulsed field ablation: toward temperature-aware workflows and reproducible reporting.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026Article
- The effect of inter-pulse delay on lesion size: a step towards demystifying pulsed field ablation.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026Article
- Real-World Adverse Events Associated With the Sphere-9 Dual-Energy Arrhythmia Ablation Catheter.Journal of cardiovascular electrophysiology · 2026Article
- A Review of Potential Complications of Pulsed Field Ablation for AF: Beneath the Surface.Arrhythmia & electrophysiology review · 2026Review
- Pulsed Field Ablation in Patients With Cardiac Implantable Electric Devices: Vigilance Is Warranted.Pacing and clinical electrophysiology : PACE · 2026Review
- Microbubble Formation and Hemolysis in Pulsed Field Ablation for Treating Arrhythmia: Risks, Mechanisms, and Prevention.Pacing and clinical electrophysiology : PACE · 2026Review
- Atrial fibrillation: from pathogenesis to novel treatment options.Molecular biomedicine · 2025Review
- An Ex Vivo Evaluation of Air Intrusion Into Pulsed Field Ablation Sheaths During Ablation and Mapping Catheter Insertion.Journal of cardiovascular electrophysiology · 2025Article
- Pulsed field ablation for paroxysmal supraventricular tachycardia: a systematic review and single-arm meta-analysis.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2025Review
- Risk of acute pericarditis after pulsed-field ablation pulmonary vein isolation.Heart rhythm O2 · 2025Article
- Laryngospasm During Pulsed Field Ablation of the Left Superior Pulmonary Vein.JACC. Case reports · 2025Article
- Safety profile of pulsed field ablation regarding phrenic nerve function.Heart rhythm O2 · 2025Article
- Complexity and Perplexity of Pulsed Field Ablation: An Engineering Perspective.Arrhythmia & electrophysiology review · 2025Review
- State of the Journal 2025.Heart rhythm O2 · 2025Article
- Proactive esophageal cooling during radiofrequency cardiac ablation: data update including applications in very high-power short duration ablation.Expert review of medical devices · 2025Review
- Reply: Safety profile of pulsed field ablation regarding phrenic nerve function.Heart rhythm O2 · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The introduction of pulsed field ablation (PFA) in electrophysiology marks a significant advancement, promising efficacy comparable to thermal ablation methods while potentially providing safety advantages. Despite a generally favorable safety profile in human trials and postmarket registries, cautious evaluation of PFA's safety is essential. This review provides a comprehensive overview of key safety considerations as we discuss a myriad of considerations ranging from thermal effects, gaseous microbubble formation, muscle contractions, and proarrhythmia to procedural techniques. We explore specific safety concerns with phrenic nerve injury, cerebral lesions, coronary artery spasm, hemolysis and pulmonary bleeding. Vigilance in safety monitoring, coupled with advancements in procedural techniques and understanding of PFA's unique effects, is crucial for optimizing the safe and effective use of PFA.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.