Evidence map›Paper›PMID 39493726›Full record

ArticleTherapeutic advances in infectious disease

Impact of an antibiotic stewardship program on adherence to antibiotic prescription in children admitted with urinary tract infection.

Giulia Brigadoi, Cecilia Liberati, Emelyne Gres, Elisa Barbieri, Elena Boreggio, Sara Rossin, Francesca Tirelli, Francesca Tesser, Lorenzo Chiusaroli, Giulia Camilla Demarin and 5 more

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In one paragraph

Article in Therapeutic advances in infectious disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Giulia BrigadoiDivision of Pediatric Infectious Diseases, Department for Women's and Children's Health, University of Padua, Padova 35128, Italy.ORCID https://orcid.org/0009-0004-0600-7745
Cecilia LiberatiDivision of Pediatric Infectious Diseases, Department for Women's and Children's Health, University of Padua, Padova, Italy.
Emelyne GresCERPOP, UMR, Inserm, University of Toulouse, Toulouse, France.
Elisa BarbieriDivision of Pediatric Infectious Diseases, Department for Women's and Children's Health, University of Padua, Padova, Italy.
Elena BoreggioDepartment for Women's and Children's Health, University of Padua, Padova, Italy.
Sara RossinPediatric Emergency Department, Department for Women's and Children's Health, University of Padua, Padova, Italy.
Francesca TirelliPediatric Emergency Department, Department for Women's and Children's Health, University of Padua, Padova, Italy.
Francesca TesserDepartment for Women's and Children's Health, University of Padua, Padova, Italy.
Lorenzo ChiusaroliDivision of Pediatric Infectious Diseases, Department for Women's and Children's Health, University of Padua, Padova, Italy.
Giulia Camilla DemarinDepartment for Women's and Children's Health, University of Padua, Padova, Italy.
Linda MaestriDepartment for Women's and Children's Health, University of Padua, Padova, Italy.
Carlo GiaquintoDivision of Pediatric Infectious Diseases, Department for Women's and Children's Health, University of Padua, Padova, Italy.
Liviana Da DaltPediatric Emergency Department, Department for Women's and Children's Health, University of Padua, Padova, Italy.
Silvia BressanPediatric Emergency Department, Department for Women's and Children's Health, University of Padua, Padova, Italy.
Daniele DonàDivision of Pediatric Infectious Diseases, Department for Women's and Children's Health, University of Padua, Padova, Italy.ORCID https://orcid.org/0000-0001-7105-2105

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Urinary tract infections (UTIs) are the most common bacterial infections in children. The high variability in pathogen susceptibility rates leads to the lack of clear guidelines for empiric and targeted therapies. In this view, local microbiological surveillance and locally adapted stewardship interventions need to be implemented. Objective: The study aims to describe the results of a pediatric antimicrobial stewardship program on antibiotic prescriptions for UTIs over 8 years in a pediatric general ward of a tertiary center. Design: This quasi-experimental study was conducted between 2015 and 2022, with two different implementations, one in 2018 and one in 2021. Methods: Demographic, clinical, microbiological, and therapeutic data were retrieved from the electronic clinical records of included patients. The primary outcomes were adherence to local guidelines for empiric therapies and the adequacy of targeted therapy. Secondary outcomes were evaluating antibiotic prescription patterns stratified by antibiotics during hospital stay and at discharge, and assessing the microbiological characteristics of UTI episodes. Results: During the study period, 7038 patients were admitted to the pediatric acute care unit (PACU), and 264 (3.7%) were included in this study. Adherence to local guidelines was highest immediately after the interventions, and it slightly decreased thereafter. Use of cephalosporins remained high throughout the 8 years but the changing microbiological scenario observed led to changing recommendations within the study period. An increase in Conclusion: The variability of antimicrobial consumption reflects the changing resistance patterns for UTIs pathogens, underlying the importance of locally adapted, persevering antimicrobial stewardship interventions.

Indexed as

adherenceantibioticsantimicrobial stewardship programchildrenurinary tract infection

Identifiers

PMID39493726
PMCPMC11528598

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.