Evidence map›Paper›PMID 39493568›Full record

ReviewWorld journal of diabetes2024

Role of cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes pathway in diabetes and its complications.

Ming-Wei Fan, Jin-Lan Tian, Tan Chen, Can Zhang, Xin-Ru Liu, Zi-Jian Zhao, Shu-Hui Zhang, Yan Chen

Abstract readReview
In one paragraph

Review in World journal of diabetes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Physiological Significance and Functions of AA.Reviews of physiology, biochemistry and pharmacology · 2027
    Review
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ming-Wei FanDepartment of Gastroenterology, Binzhou Medical University Hospital, Binzhou 256600, Shandong Province, China.
Jin-Lan TianDepartment of Gastroenterology, Binzhou Medical University Hospital, Binzhou 256600, Shandong Province, China.
Tan ChenDepartment of Gastroenterology, Binzhou Medical University Hospital, Binzhou 256600, Shandong Province, China.
Can ZhangDepartment of Gastroenterology, Binzhou Medical University Hospital, Binzhou 256600, Shandong Province, China.
Xin-Ru LiuDepartment of Gastroenterology, Binzhou Medical University Hospital, Binzhou 256600, Shandong Province, China.
Zi-Jian ZhaoDepartment of Gastroenterology, Binzhou Medical University Hospital, Binzhou 256600, Shandong Province, China.
Shu-Hui ZhangDepartment of Gastroenterology, Binzhou Medical University Hospital, Binzhou 256600, Shandong Province, China.
Yan ChenDepartment of Gastroenterology, Binzhou Medical University Hospital, Binzhou 256600, Shandong Province, China. chenyanfeihong0906@163.com. chenyanfeihong0906@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes mellitus (DM) is one of the major causes of mortality worldwide, with inflammation being an important factor in its onset and development. This review summarizes the specific mechanisms of the cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)-stimulator of interferon genes (STING) pathway in mediating inflammatory responses. Furthermore, it comprehensively presents related research progress and the subsequent involvement of this pathway in the pathogenesis of early-stage DM, diabetic gastroenteropathy, diabetic cardiomyopathy, non-alcoholic fatty liver disease, and other complications. Additionally, the role of cGAS-STING in autonomic dysfunction and intestinal dysregulation, which can lead to digestive complications, has been discussed. Altogether, this study provides a comprehensive analysis of the research advances regarding the cGAS-STING pathway-targeted therapeutic agents and the prospects for their application in the precision treatment of DM.

Indexed as

Cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genesDiabetes cardiovascular diseaseDiabetes gastroenteropathyDiabetes mellitusDiabetes nephropathyGlycolipid metabolismInflammationNonalcoholic fatty liver disease

Identifiers

PMID39493568
PMCPMC11525733

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.