Evidence map›Paper›PMID 39493549›Full record

ArticleRSC advances2024

LC-MS/MS characterization of pirtobrutinib impurities and product degradation: stability studies.

Modachakanahally K Pavithra, Chaya G, Hemavathi N Deepakumari, Hosakere D Revanasiddappa, Salah Jasim Mohammed, Hasan Sh Majdi, Abdullah H Alsabhan, Shareefraza J Ukkund

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Article in RSC advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Modachakanahally K PavithraDepartment of Chemistry, Bharathi College Bharathinagara Mandya 571 422 Karnataka India pavithramk664@gmail.com chayaguruswamy97@gmail.com.
Chaya GDepartment of Chemistry, Bharathi College Bharathinagara Mandya 571 422 Karnataka India pavithramk664@gmail.com chayaguruswamy97@gmail.com.
Hemavathi N DeepakumariDepartment of Chemistry, Bharathi College Bharathinagara Mandya 571 422 Karnataka India pavithramk664@gmail.com chayaguruswamy97@gmail.com.ORCID https://orcid.org/0000-0001-9189-2099
Hosakere D RevanasiddappaDepartment of Chemistry, University of Mysore Manasagangotri Mysuru 570 006 Karnataka India hdrevanasiddappa@yahoo.com.
Salah Jasim MohammedCivil Engineering Department, Dijlah University College Baghdad 00964 Iraq salah.jasmin@duc.edu.iq.ORCID https://orcid.org/0009-0000-6833-3774
Hasan Sh MajdiDepartment of Chemical Engineering and Petroleum Industries, Al-Mustaqbal University College Babylon 51001 Iraq mn13022020@gmail.com.ORCID https://orcid.org/0000-0001-6752-4835
Abdullah H AlsabhanDepartment of Civil Engineering, College of Engineering, King Saud University Riyadh 11421 Saudi Arabia aalsabhan@ksu.edu.sa.
Shareefraza J UkkundDepartment of Biotechnology, P.A. College of Engineering Mangalore 574153 India drshareef2022@gmail.com.ORCID https://orcid.org/0000-0002-5678-7426

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study examined the fragmentation, degradation pathways and DPs of pirtobrutinib, which have not been previously reported in the literature. The main goal of the current work is to develop, validate, and characterize forced degradation products using LC-MS/MS. An isocratic HPLC methodology was developed for the quantitative measurement of pirtobrutinib at a

Identifiers

PMID39493549
PMCPMC11528333

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.