Evidence map›Paper›PMID 39493444›Full record

ArticleAmerican heart journal plus : cardiology research and practice2024

The role of cholesterol crystals and ocular crystal emboli in retinal pathology.

Nicholas G Medawar, Tim F Dorweiler, George S Abela, Julia V Busik, Maria B Grant

Abstract read
In one paragraph

Article in American heart journal plus : cardiology research and practice, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nicholas G MedawarUniversity of Alabama at Birmingham, Department of Visual Sciences and Ophthalmology, Birmingham, AL, United States of America.
Tim F DorweilerBoston Children's Hospital, Department of Surgery, Cambridge, MA, United States of America.
George S AbelaMichigan State University, Department of Medicine, College of Human Medicine, East Lansing, MI, United States of America.
Julia V BusikUniversity of Oklahoma, Department of Biochemistry and Physiology, Oklahoma City, OK, United States of America.
Maria B GrantUniversity of Alabama at Birmingham, Department of Visual Sciences and Ophthalmology, Birmingham, AL, United States of America.

Funding

Visual Phenotyping CoreP30EY003039 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Paul Douglas Gamlin · 1985 to 2026
$16.9M
NITRIC OXIDE IN THE PATHOGENESIS OF DIABETIC RETINOPATHYR01EY012601 · NEI · UNIVERSITY OF FLORIDA · PI Julia V Busik, Maria Bartolomeo Grant · 1998 to 2026
$9.6M
Dyslipidemia and Diabetic RetinopathyR01EY016077 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI BUSIK, JULIA V · 2005 to 2025
$6.3M
ACE2 on gut barrier dysfunction and BRB disruptionR01EY032753 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Michael Edwin Boulton, Maria Bartolomeo Grant · 2022 to 2026
$1.8M
NEI NIH HHS P30 EY003039NEI NIH HHS R01 EY012601NEI NIH HHS R01 EY016077NEI NIH HHS R01 EY032753
6 · The paper itself

Abstract

Cholesterol crystals (CC) can be responsible for a range of clinical syndromes in the retina from asymptomatic plaques to retinal artery occlusion with clinical trials providing evidence for the efficacy in lipid lowering therapies in preventing ocular pathology. Much of the literature has focused on CC in retinal circulation as a marker of poor systemic health and have attempted to use them to categorize risk of mortality and stroke. More recently cholesterol accumulation and CC formation have been linked to development of diabetic retinopathy with CC formation in the retina due to aberrant retinal cholesterol homeostasis and not simply systemic dyslipidemia.

Identifiers

PMID39493444
PMCPMC11530860

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.