Evidence map›Paper›PMID 39493254›Full record

ArticleTherapeutic advances in ophthalmology

Optical coherence tomography angiography to assess for retinal vascular changes in Neuro-Sjögren.

Melanie Haar, Franz Felix Konen, Marten A Gehlhaar, Irene Oluwatoba-Popoola, Emilia Donicova, Marija Wachsmann, Ahmed Lubbad, Katerina Hufendiek, Amelie Pielen, Bettina Hohberger and 9 more

Abstract read
In one paragraph

Article in Therapeutic advances in ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Melanie HaarDepartment of Ophthalmology, Hannover Medical School, Carl-Neuberg-Straße 1, Hannover 30625, Germany.ORCID https://orcid.org/0009-0001-8402-2818
Franz Felix KonenDepartment of Neurology, Hannover Medical School, Hannover, Germany.
Marten A GehlhaarDepartment of Ophthalmology, Hannover Medical School, Hannover, Germany.
Irene Oluwatoba-PopoolaDepartment of Ophthalmology, Hannover Medical School, Hannover, Germany.
Emilia DonicovaDepartment of Ophthalmology, Hannover Medical School, Hannover, Germany.
Marija WachsmannDepartment of Ophthalmology, Hannover Medical School, Hannover, Germany.
Ahmed LubbadDepartment of Ophthalmology, Hannover Medical School, Hannover, Germany.
Katerina HufendiekDepartment of Ophthalmology, Hannover Medical School, Hannover, Germany.
Amelie PielenDepartment of Ophthalmology, Hannover Medical School, Hannover, Germany.
Bettina HohbergerDepartment of Ophthalmology, Universitätsklinkum Erlangen, Erlangen, Germany.
Christian MardinDepartment of Ophthalmology, Universitätsklinkum Erlangen, Erlangen, Germany.
Stefan GingeleDepartment of Neurology, Hannover Medical School, Hannover, Germany.
Nils K PrenzlerDepartment of Otolaryngology, Hannover Medical School, Hannover, Germany.
Diana ErnstDepartment of Rheumatology & Immunology, Hannover Medical School, Hannover, Germany.
Torsten WitteDepartment of Rheumatology & Immunology, Hannover Medical School, Hannover, Germany.
Carsten FrammeDepartment of Ophthalmology, Hannover Medical School, Hannover, Germany.
Thomas SkripuletzDepartment of Neurology, Hannover Medical School, Hannover, Germany.
Tabea SeeligerDepartment of Neurology, Hannover Medical School, Hannover, Germany.
Anna BajorDepartment of Ophthalmology, Hannover Medical School, Hannover, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Sjögren's syndrome is an autoimmune disease characterized by sicca symptoms and various extraglandular manifestations including vasculitis. Neurological involvement occurs frequently (Neuro-Sjögren) and often mimics immune neuropathies such as chronic inflammatory demyelinating polyneuropathy (CIDP). Objectives: We aim to assess relevant differences in vessel density (VD) in Optical Coherence Tomography Angiography (OCTA) in those diseases to use it as an easily available diagnostic tool. Design: Prospective, monocentric pilot-study. Methods: OCTA (Heidelberg Engineering OCT SPECTRALIS) of the superficial vascular plexus, intermediate capillary plexus (ICP) and deep capillary plexus (DCP) of the retina was prospectively performed in Neuro-Sjögren, age-matched CIDP patients ( Results: Significantly lower VD were found for the DCP and ICP in Neuro-Sjögren and CIDP patients compared to healthy controls ( Conclusion: This study found no significant differences in VD or the foveal avascular zone between Neuro-Sjögren and CIDP patients using OCTA, suggesting that inflammatory vascular changes in the retina are uncommon in Neuro-Sjögren patients.

Indexed as

chronic inflammatory demyelinating polyneuropathyneuro-Sjögrenoptical coherence tomography angiographyretinal vasculatureSjögren’s syndromevasculitis

Identifiers

PMID39493254
PMCPMC11528602

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.