Evidence map›Paper›PMID 39493145›Full record

ArticleCureus2024

Diphenhydramine Overdose: A Case Report and Topic Review of Prehospital Diagnosis and Treatment.

Marshall A Frank, Jeremy Lund, David M Langley, Mitchell Annis, Tamas R Peredy

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Marshall A FrankEmergency Medicine, Florida State University College of Medicine, Sarasota, USA.
Jeremy LundToxicology, Sarasota Memorial Hospital, Sarasota, USA.
David M LangleyEmergency Medicine, Florida State University College of Medicine, Sarasota, USA.
Mitchell AnnisEmergency Medicine, Florida State University College of Medicine, Sarasota, USA.
Tamas R PeredyEmergency Medicine, Florida State University College of Medicine, Sarasota, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diphenhydramine (DPH), a readily available first-generation H1 receptor antihistamine, can have severe consequences when taken in excessive amounts and can lead to grave outcomes such as seizures, dysrhythmias, coma, and death. Recognizing the early signs and symptoms of DPH toxicity is crucial. Fortunately, fatal adult cases of DPH overdose are rare. This report describes a near-fatal overdose of a young adult female who experienced recurrent seizures, respiratory failure, and cardiac arrest with the return of spontaneous circulation (ROSC) in the prehospital setting and complete functional recovery. This case underscores the urgency of addressing DPH toxicity and the utility of reversal agents, such as sodium bicarbonate, in sodium channel blockade.

Indexed as

anticholinergic toxidromecritical care transportdiphenhydramine overdoselipid emulsionout-of-hospital cardiac arrestprehospital emergency medicineseizuresodium bicarbonatewide complex tachycardia

Identifiers

PMID39493145
PMCPMC11530281

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.