ArticleCureus2024
Evaluating the Diagnostic Utility of Serum Laboratory Studies and Synovial Fluid Analysis in Identifying Periprosthetic Joint Infection in Metal Hip Revisions.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Metal-on-metal (MoM) bearing surfaces have been implicated as a cause of increased complication rates in total hip arthroplasty (THA), with local and systemic reactions identified. These reactions may cause abnormal laboratory results in common tests that are used to diagnose periprosthetic joint infection (PJI). The purpose of this study was to evaluate the utility of common laboratory studies in the diagnosis of PJI in patients undergoing revision THA with MoM bearings. Methods A retrospective case series of 81 patients undergoing THA revision of MoM bearings from January 2010 to May 2023 at a single institution was performed. Patient data was extracted from the electronic medical record. All patients were evaluated using the 2018 International Consensus Meeting (ICM) definition of PJI. Descriptive statistics were calculated for the clinical characteristics of all patients. Univariate analyses were performed to compare patients who met the ICM criteria for infection with those deemed indeterminate. Results Fifty-one (63.0%) patients were deemed not infected according to ICM criteria, 19 (23.5%) were deemed indeterminate, and 11 (13.6%) were deemed infected. Clinically, four patients had two or more positive cultures and were formally treated for PJI; all patients were deemed inconclusive, and the remaining seven patients deemed infected were clinically treated as not infected, and all remained infection-free. There were significant differences between patients deemed inconclusive and those deemed infected in synovial WBC count (17,539 vs. 90,196 cells/μL, p = 0.049) and synovial polymorphonuclear (PMN) neutrophils (38 vs. 79%, p = 0.002). No other significant differences in laboratory values or outcomes were noted between groups. Conclusions Patients undergoing revision THA with MoM bearings may be more likely to present with a clinical picture that is concerning for infection and may benefit from a more aggressive preoperative workup. The synovial PMN neutrophil percentage may help differentiate between hips that are infected and those that are not.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.