ArticleOrthopaedic surgery2024
Musculoskeletal Multimorbidity Burden and Trajectory in Relation to Later-Life Holistic Well-Being Among Middle-Aged and Elderly Individuals: A Prospective Study.
Article in Orthopaedic surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- The impact of accelerometer-derived 'weekend warrior' physical activity on musculoskeletal disorders and multimorbidity development.Journal of exercise science and fitness · 2026Article
- Quality of life in older adults with urinary incontinence and its impact on the stigma-care needs network: latent profile and network analysis.BMC geriatrics · 2026Article
- The association between solid fuel use for heating and cooking and low back pain and neck pain in middle-aged to elderly Chinese adults: a cross-sectional and panel data analysis.BMC public health · 2025Article
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5 authors.
Funding
Abstract
objectivesUnderstanding the patterns and implications of coexisting musculoskeletal conditions is crucial for developing effective management strategies and improving care for older adults. This study aimed to examine the associations between musculoskeletal multimorbidity burden and trajectory and holistic well-being among middle-aged and older adults.
methodsThis prospective study employed data from nine consecutive waves of the English Longitudinal Study of Aging (ELSA), spanning 2002-2018. We used latent class trajectory models (LCTM) to identify groups based on changes in musculoskeletal multimorbidity status. Subsequently, we employed linear mixed models to investigate the associations between musculoskeletal disease burden, trajectory groups, and seven dimensions of holistic well-being: Activities of Daily Living (ADLs), Instrumental Activities of Daily Living (IADLs), depression, memory, loneliness, social interactions, and life satisfaction.
resultsIn total, 5272 participants (mean age: 71.9 years; SD: 8.9) were included in the final analysis. Four distinct trajectories were identified: a low-burden group (48.37%), an emerging group (14.76%), a moderate-burden group (26.00%), and a persistent burden group (10.87%). After adjustment, the findings demonstrate that the musculoskeletal disorder burden significantly impacts ADLs, depression, memory, social interactions, and life satisfaction in middle-aged and older adults, with minor effects on IADLs and loneliness. Moreover, with the escalation of the burden, its impact significantly intensifies (p for trend is < 0.001). Compared with the low-burden group, participants in both the moderate and persistent burden groups exhibited significantly lower capabilities in ADLs, poorer memory, increased social interactions, and lower life satisfaction. The emerging group displayed a similar trend, though without statistically significant results.
conclusionsOur study suggests that the extent and persistence of musculoskeletal disease burden can significantly affect holistic well-being among middle-aged and older individuals.
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