Evidence map›Paper›PMID 39492768›Full record

SynthesisCurrent cardiology reviews2025

Heart Rate Variability and Heart Failure with Reduced Ejection Fraction: A Systematic Review of Literature.

Michiaki Nagai, Hallum Ewbank, Yukiko Nakano, Benjamin J Scherlag, Sunny S Po, Tarun W Dasari

Registry-linked trialAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Current cardiology reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07591935 (Artificial Intelligence and Mindfulness Meditation), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07591935 nacompletednot on this map

Artificial Intelligence and Mindfulness Meditation: Innovative Methods to Reduce Stress Amongst Medical School Students

TypeinterventionalSponsorSaint James School of MedicineRan2024 to 2024Enrolled20ConditionsStressArmsMindfulness-Based Stress Reduction Course, Apollo Neuro Wearable
3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Michiaki NagaiCardiovascular Section, Department of Medicine, University of Oklahoma Health Science Center, Oklahoma, OK 73104, USA.
Hallum EwbankCollege of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, OK 73104, USA.
Yukiko NakanoDepartment of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Benjamin J ScherlagCardiovascular Section, Department of Medicine, University of Oklahoma Health Science Center, Oklahoma, OK 73104, USA.
Sunny S PoCardiovascular Section, Department of Medicine, University of Oklahoma Health Science Center, Oklahoma, OK 73104, USA.
Tarun W DasariCardiovascular Section, Department of Medicine, University of Oklahoma Health Science Center, Oklahoma, OK 73104, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAutonomic impairment is a hallmark of heart failure with reduced ejection fraction (HFrEF). While there have been studies on general values for each index of heart rate variability (HRV) analysis in HFrEF, a systematic review comprehensively examining representative values in HFrEF is lacking.

methodsWe searched PubMed, Embase, and Cochrane databases to extract studies reporting representative values of HRV metrics in HFrEF.

resultsA total of 470 HFrEF patients from 6 studies were included in the review. In general, time and frequency domains were abnormally lower in HFrEF, portending a worse prognosis. In HFrEF, the mean or median value of the standard deviation of NN interval, root mean square successive difference, pNN50, and low-frequency power/high-frequency power were 40 to 121 msec, 19 to 62 msec, 1.3 to 14%, and 1.00 to 1.73, respectively.

conclusionIn this systematic review, most HRV metrics were found to be calculated from 24- hour Holter recordings and were lower in HFrEF patients with poor prognosis.

Indexed as

Autonomic Nervous SystemHeart FailureHeart RateStroke VolumeHumansPrognosisautonomic nervousheart failure with reduced ejection fractionHeart rate variabilityHF phenotypesympathetic nervous systemvagus nervous system

Identifiers

PMID39492768
PMCPMC12060912

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.