ReviewCurrent medicinal chemistry2025
Chemical Synthesis and Enzymatic Modification of Mangostins: A Comprehensive Review on Structural Modifications for Drug Discovery.
Review in Current medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Exploring the Multitarget Therapeutic Potential of Mangostin Derivatives.Current medicinal chemistry · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Mangostins, a prominent component of Garcinia mangostana, have been extensively studied for their biological activities and structural modifications. Chemical methods, including cyclization reactions under acidic conditions, have yielded many derivatives, which often exhibit enhanced pharmacological properties compared to itself. Enzymatic biotransformation, such as glycosylation and oxidation mediated by fungal species and enzymes like horseradish peroxidase, have provided regioselective pathways to functionalized mangostin derivatives. These studies highlight the versatility of mangostin as a scaffold for designing compounds with tailored biological functions. Overall, mangostin represent a promising platform for developing compounds with enhanced pharmacological activities, paving the way for innovative approaches in biomedicine and pharmaceutical sciences. This review provides a comprehensive examination of the chemistry of mangostins, detailing their total synthesis and the derivatives obtained through both chemical and enzymatic methodologies.
Indexed as
Identifiers
39492765What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.