Evidence map›Paper›PMID 39491745›Full record

ArticleModern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc2025

Refining Diagnostic Subtypes of Peripheral T-Cell Lymphoma Using a Multiparameter Approach.

Catalina Amador, Dennis D Weisenburger, Ana Gomez, Alyssa Bouska, Ahmad Alshomrani, Sunandini Sharma, Ab Rauf Shah, Timothy C Greiner, Francisco Vega, Andreas Rosenwald and 18 more

Abstract read
In one paragraph

Article in Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Peripheral T-Cell Lymphoma, Not Otherwise Specified, Diagnosed from Prostate Tissue: A Rare CaseTurkish journal of haematology : official journal of Turkish Society of Haematology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Catalina AmadorDepartment of Pathology and Laboratory Medicine, University of Miami Miller School of Medicine, Miami, Florida. Electronic address: catalina.amador@med.miami.edu.
Dennis D WeisenburgerDepartment of Pathology, Microbiology and Immunology, University of Nebraska Medical Center, Omaha, Nebraska.
Ana GomezDepartment of Pathology and Laboratory Medicine, University of Miami Miller School of Medicine, Miami, Florida.
Alyssa BouskaDepartment of Pathology, Microbiology and Immunology, University of Nebraska Medical Center, Omaha, Nebraska.
Ahmad AlshomraniDepartment of Pathology, Microbiology and Immunology, University of Nebraska Medical Center, Omaha, Nebraska.
Sunandini SharmaDepartment of Pathology, Microbiology and Immunology, University of Nebraska Medical Center, Omaha, Nebraska.
Ab Rauf ShahDepartment of Pathology, Microbiology and Immunology, University of Nebraska Medical Center, Omaha, Nebraska.
Timothy C GreinerDepartment of Pathology, Microbiology and Immunology, University of Nebraska Medical Center, Omaha, Nebraska.
Francisco VegaDepartment of Hematopathology, Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Andreas RosenwaldInstitute of Pathology, University of Würzburg, Würzburg, Germany; Comprehensive Cancer Center Mainfranken, Würzburg, Germany.
German OttDepartment of Clinical Pathology, Robert-Bosch Krankenhaus, Stuttgart, Germany; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.
Andrew L FeldmanDepartment of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine and Science, Rochester, Minnesota.
Elaine S JaffeLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.
Neval OzkayaLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.
Sarah L OndrejkaPathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, Ohio.
James R CookPathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, Ohio.
Philipp W RaessDepartment of Pathology and Laboratory Medicine, Oregon Health and Science University, Portland, Oregon.
Kerry J SavageCenter for Lymphoid Cancer, British Columbia Cancer, Vancouver, British Columbia, Canada.
Graham W SlackCenter for Lymphoid Cancer, British Columbia Cancer, Vancouver, British Columbia, Canada.
Joo Y SongDepartment of Pathology, City of Hope National Medical Center, Duarte, California.
David W ScottCenter for Lymphoid Cancer, British Columbia Cancer, Vancouver, British Columbia, Canada.
Elias CampoHematopathology Unit, Hospital Clinic, Barcelona, Spain; Institute of Biomedical Research August Pi i Sunyer, University of Barcelona, Barcelona, Spain.
Lisa M RimszaDepartment of Laboratory Medicine and Pathology, Mayo Clinic Arizona, Scottsdale, Arizona.
Joseph D KhouryDepartment of Pathology, Microbiology and Immunology, University of Nebraska Medical Center, Omaha, Nebraska.
Louis M StaudtMetabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Wing C ChanDepartment of Pathology, City of Hope National Medical Center, Duarte, California.
Javeed IqbalDepartment of Pathology, Microbiology and Immunology, University of Nebraska Medical Center, Omaha, Nebraska. Electronic address: jiqbal@unmc.edu.
Leukemia and Lymphoma Molecular Profiling Project Consortium

Funding

UNMC/EPPLEY CANCER CENTER SUPPORT GRANTP30CA036727 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Joann B. Sweasy · 1985 to 2026
$55.0M
Preclinical Models and Therapeutics CoreP01CA229100 · NCI · MAYO CLINIC ARIZONA · PI SCOTT, DAVID WILLIAM · 2018 to 2022
$10.2M
Cooperative role of TET2 and IDH2 mutations in angioimmunoblastic T-cell lymphomagenesisR01CA251412 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI IQBAL, JAVEED, SONG, JOO · 2021 to 2025
$2.4M
Pre-analytical variables of bioanalytes affecting the accuracy of PTCL diagnostic and prognostic genetic signaturesU01CA253218 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI IQBAL, JAVEED, MURTAZA, MUHAMMED · 2021 to 2025
$1.8M
Molecular diagnostic and prognostic signatures for PTCLUH3CA206127 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI CHAN, WING C., IQBAL, JAVEED · 2019 to 2021
$864k
Molecular diagnostic and prognostic signatures for PTCLUH2CA206127 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI CHAN, WING C., IQBAL, JAVEED · 2017 to 2018
$397k
Development of a Novel Clinical Diagnostic Assay for Peripheral T-cell Lymphoma (PTCL)R41CA221466 · NCI · HEALTHCHART, LLC · PI CHAN, WING C., IQBAL, JAVEED · 2018 to 2018
$299k
NCI NIH HHS P01 CA229100NCI NIH HHS P30 CA036727NCI NIH HHS R01 CA251412NCI NIH HHS R41 CA221466NCI NIH HHS U01 CA253218NCI NIH HHS UH2 CA206127NCI NIH HHS UH3 CA206127
6 · The paper itself

Abstract

Peripheral T-cell lymphoma (PTCL) is a heterogeneous group of neoplasms, with many cases remaining unclassifiable and categorized as PTCL-not otherwise specified (PTCL-NOS). Gene expression profiling (GEP) has delineated 2 prognostic subtypes within PTCL-NOS, PTCL-TBX21 and PTCL-GATA3, characterized by distinctive transcriptomes and a different prognosis. To further evaluate the pathologic features of these subgroups, 101 PTCL cases that did not meet specific criteria for well-defined T-cell lymphoma entities underwent detailed pathologic, immunophenotypic (including T follicular helper [T

Indexed as

Biomarkers, TumorLymphoma, T-Cell, PeripheralAdultAgedAged, 80 and overFemaleGATA3 Transcription FactorGene Expression ProfilingHumansImmunophenotypingMaleMiddle AgedTranscriptomeYoung AdultBiomarkers, TumorGATA3 protein, humanGATA3 Transcription Factorlymphomaperipheral T-cell lymphomaPTCL-GATA3PTCL-TBX21T follicular helper

Identifiers

PMID39491745
PMCPMC11845303

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.