Evidence map›Paper›PMID 39491631›Full record

ArticleNeurobiology of disease2024

Differential induction of Parieto-motor plasticity in writer's cramp and cervical dystonia.

Hyun Joo Cho, Hae-Won Shin, Pattamon Panyakaew, Panagiotis Kassavetis, Traian Popa, Tianxia Wu, Giorgio Leodori, Terance Camacho, Shivangi Singh, Sabine Meunier and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Pathophysiology of dystonia: Through the lens of Mark Hallett.Clinical parkinsonism & related disorders · 2026
    Review
  3. Brain network pathophysiology in dystonia.Dystonia (Lausanne, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hyun Joo ChoDivision of Intramural Research, NINDS, National Institutes of Health, Bethesda, MD, USA.
Hae-Won ShinDivision of Intramural Research, NINDS, National Institutes of Health, Bethesda, MD, USA; Department of Neurology, Chung-Ang University College of Medicine, Seoul, Republic of Korea.
Pattamon PanyakaewDivision of Intramural Research, NINDS, National Institutes of Health, Bethesda, MD, USA; Chulalongkorn Center of Excellence for Parkinson's Disease & Related Disorders, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok 10330, Thailand.
Panagiotis KassavetisDivision of Intramural Research, NINDS, National Institutes of Health, Bethesda, MD, USA; Department of Neurology, University of Utah Health, UT, USA.
Traian PopaDivision of Intramural Research, NINDS, National Institutes of Health, Bethesda, MD, USA; Department of Clinical Neurosciences, Lausanne University Hospital (CHUV), Switzerland.
Tianxia WuDivision of Intramural Research, NINDS, National Institutes of Health, Bethesda, MD, USA.
Giorgio LeodoriDivision of Intramural Research, NINDS, National Institutes of Health, Bethesda, MD, USA; Department of Human Neurosciences, Sapienza University of Rome, Italy.
Terance CamachoDivision of Intramural Research, NINDS, National Institutes of Health, Bethesda, MD, USA; University of Maryland School of Medicine, USA.
Shivangi SinghDivision of Intramural Research, NINDS, National Institutes of Health, Bethesda, MD, USA; Columbia University Medical Center, NY, USA.
Sabine MeunierDivision of Intramural Research, NINDS, National Institutes of Health, Bethesda, MD, USA; Sorbonne Université, France Institut du Cerveau - Paris Brain Institute - ICM, France Inserm, France CNRS, Paris, France.
Mark HallettDivision of Intramural Research, NINDS, National Institutes of Health, Bethesda, MD, USA. Electronic address: hallettm@ninds.nih.gov.

Funding

Pathophysiology of Basal Ganglia DisordersZ01NS003031 · NINDS · NEUROLOGICAL DISORDERS AND STROKE · PI HALLETT, MARK · 2007 to 2008
$4.4M
Intramural NIH HHS Z01 NS003031
6 · The paper itself

Abstract

objectivesTo investigate the plastic effects of parieto-motor (PAR-MOT) cortico-cortical paired associative paired stimulation (cc-PAS) in patients with two forms of focal dystonia, writer's cramp and cervical dystonia, compared to healthy volunteers (HVs).

methodsWe used cc-PAS to induce associative plasticity using repeated time-locked paired transcranial magnetic stimulation (TMS) pulses over the parietal and motor cortices in 16 patients with writer's cramp (WC), 13 patients with cervical dystonia (CD), and 23 healthy volunteers. We measured parieto-motor corticocortical connectivity using posterior parietal cortex (PPC) to primary motor cortex (M1) facilitation and input-output curves (IOC) of the motor-evoked potential (MEP) before and after PAR-MOT cc-PAS. The PAR-MOT cc-PAS consisted of 100 pairs of TMS pulses every 5 s, with the conditioning pulse applied to the left angular gyrus in the intraparietal sulcus and the test pulse applied to the M1 hotspot of the first dorsal interosseous muscle.

resultsThe cc-PAS increased the area under the IOC by increasing its maximum level in patients with WC but not in patients with CD or healthy volunteers. The cc-PAS had no significant effect on other IOC parameters. There were no significant differences in PPC to M1 facilitation changes after PAR-MOT cc-PAS among all groups.

conclusionsThis study suggests that PAR-MOT cc-PAS abnormally increases M1 excitability in patients with WC but not in those with CD. Additionally, this increased plastic response in patients with WC does not appear to be directly linked to PPC to M1 corticocortical connectivity.

Indexed as

Dystonic DisordersEvoked Potentials, MotorMotor CortexNeuronal PlasticityParietal LobeTorticollisTranscranial Magnetic StimulationAdultAgedFemaleHumansMaleMiddle AgedCervical dystoniaParieto-motor associative plasticityParieto-motor connectivitywriter's cramp

Identifiers

PMID39491631
PMCPMC11578765

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.