Evidence map›Paper›PMID 39490919›Full record

ArticleJournal of molecular biology2024

Conformational Differences in the Light Chain Constant Domain of Immunoglobulin G and Free Light Chain May Influence Proteolysis in AL Amyloidosis.

Elena S Klimtchuk, Tatiana Prokaeva, Brian H Spencer, Sherry Wong, Shreya Ghosh, Angela Urdaneta, Gareth Morgan, Thomas E Wales, Olga Gursky

Abstract read
In one paragraph

Article in Journal of molecular biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Elena S KlimtchukAmyloidosis Center, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA 02118, United States. Electronic address: klimtchu@bu.edu.
Tatiana ProkaevaAmyloidosis Center, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA 02118, United States; Department of Pathology and Laboratory Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, United States. Electronic address: prokaeva@bu.edu.
Brian H SpencerAmyloidosis Center, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA 02118, United States. Electronic address: bspencer@bu.edu.
Sherry WongAmyloidosis Center, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA 02118, United States. Electronic address: sw671@bu.edu.
Shreya GhoshDepartment of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, United States. Electronic address: sh.ghosh@northeastern.edu.
Angela UrdanetaDepartment of Pharmacology, Physiology & Biophysics, Chobanian & Avedisian School of Medicine, Boston University, 700 Albany Street, Boston, MA 02118, United States. Electronic address: angelau@bu.edu.
Gareth MorganAmyloidosis Center, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA 02118, United States. Electronic address: gjmorgan@bu.edu.
Thomas E WalesDepartment of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, United States. Electronic address: T.Wales@northeastern.edu.
Olga GurskyDepartment of Pharmacology, Physiology & Biophysics, Chobanian & Avedisian School of Medicine, Boston University, 700 Albany Street, Boston, MA 02118, United States. Electronic address: Gursky@bu.edu.

Funding

Structural Thermodynamics of Human Apolipoprotein C-1R01GM067260 · NIGMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI GURSKY, OLGA · 2003 to 2024
$7.4M
Establishing Strategies to Ameliorate Amyloid Pathology in Light Chain AmyloidosisR01DK107604 · NIDDK · SCRIPPS RESEARCH INSTITUTE, THE · PI WISEMAN, ROCKLAND LUKE · 2016 to 2024
$4.3M
Structure and Function of Serum Amyloid A in Health and DiseaseR01GM135158 · NIGMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Olga Gursky · 2020 to 2026
$2.4M
Local dual delivery of a chemotherapy and an anti-angiogenic agent from an injectable functionalized biodegradable biomaterial system for the treatment of gliomasSC3GM135138 · NIGMS · UNIVERSITY OF TEXAS RIO GRANDE VALLEY · PI CHEW, SUE ANNE · 2020 to 2023
$436k
NIDDK NIH HHS R01 DK107604NIGMS NIH HHS R01 GM067260NIGMS NIH HHS R01 GM135158NIGMS NIH HHS SC3 GM135138
6 · The paper itself

Abstract

Immunoglobulin light chain amyloidosis (AL) is a life-threatening disease caused by the deposition of light chain (LC) and its fragments containing variable (V

Indexed as

Immunoglobulin GImmunoglobulin Light-chain AmyloidosisImmunoglobulin Light ChainsProtein ConformationProteolysisHumansImmunoglobulin Constant RegionsModels, MolecularProtein StabilityImmunoglobulin Constant RegionsImmunoglobulin GImmunoglobulin Light Chainshydrogen-deuterium exchange mass spectrometrymonoclonal antibodiesproteolysis in amyloidosisstructural stability

Identifiers

PMID39490919
PMCPMC11636358

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.