Evidence map›Paper›PMID 39490642›Full record

ArticleJournal of molecular and cellular cardiology2024

Integrated proteomics and transcriptomics analysis reveals insights into differences in premature mortality associated with disparate pathogenic RBM20 variants.

Zachery R Gregorich, Eli J Larson, Yanghai Zhang, Camila U Braz, Chunling Liu, Ying Ge, Wei Guo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular and cellular cardiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. RBM20 variants disrupt CaSignal transduction and targeted therapy · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zachery R GregorichDepartment of Animal and Dairy Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA.
Eli J LarsonDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
Yanghai ZhangDepartment of Animal and Dairy Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA.
Camila U BrazDepartment of Animal Sciences, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.
Chunling LiuDepartment of Animal and Dairy Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA.
Ying GeDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA; Human Proteomics Program, University of Wisconsin-Madison, Madison, WI 53706, USA.
Wei GuoDepartment of Animal and Dairy Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA. Electronic address: wguo2@wisc.edu.

Funding

Posttranscriptional Regulation of RNA Binding Proteins in Heart FailureR01HL148733 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI GUO, WEI · 2020 to 2023
$1.5M
American Heart Association-American Stroke Association 19TPA34830072American Heart Association-American Stroke Association 23TPA1069731NHLBI NIH HHS R01 HL148733
6 · The paper itself

Abstract

Variants in RNA binding motif protein 20 (RBM20) are causative in a severe form of dilated cardiomyopathy referred to as RBM20 cardiomyopathy, yet the mechanisms are unclear. Moreover, the reason(s) for phenotypic heterogeneity in carriers with different pathogenic variants are similarly opaque. To gain insight, we carried out multi-omics analysis, including the first analysis of gene expression changes at the protein level, of mice carrying two different pathogenic variants in the RBM20 nuclear localization signal (NLS). Direct comparison of the phenotypes confirmed greater premature morality in S639G variant carrying mice compared to mice with the S637A variant despite similar cardiac remodeling and dysfunction. Analysis of differentially spliced genes uncovered alterations in the splicing of both RBM20 target genes and non-target genes, including several genes previously implicated in arrhythmia. Global proteomics analysis found that a greater number of proteins were differentially expressed in the hearts of Rbm20

Indexed as

Gene Expression ProfilingProteomicsRNA-Binding ProteinsTranscriptomeAnimalsCardiomyopathy, DilatedGene Expression RegulationHumansMicePhenotypeRNA SplicingRBM20 protein, mouseRNA-Binding ProteinsAdverse remodelingDilated cardiomyopathyGenetic mutationsMitochondriaMultiomicsPremature mortalityProteomicsRBM20

Identifiers

PMID39490642
PMCPMC11588510

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.