Evidence map›Paper›PMID 39490401›Full record

ReviewSeminars in cancer biology2024

BubR1 and SIRT2: Insights into aneuploidy, aging, and cancer.

Renju Pun, Niti Kumari, Rodaina Hazem Monieb, Sachin Wagh, Brian J North

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Seminars in cancer biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Aging and cancer: current understandings and future perspectives.Signal transduction and targeted therapy · 2026
    Review
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Renju PunBiomedical Sciences Department, Creighton University School of Medicine, Omaha, NE, USA.
Niti KumariBiomedical Sciences Department, Creighton University School of Medicine, Omaha, NE, USA.
Rodaina Hazem MoniebBiomedical Sciences Department, Creighton University School of Medicine, Omaha, NE, USA.
Sachin WaghBiomedical Sciences Department, Creighton University School of Medicine, Omaha, NE, USA.
Brian J NorthBiomedical Sciences Department, Creighton University School of Medicine, Omaha, NE, USA. Electronic address: BrianNorth@creighton.edu.

Funding

Regulatory Mechanisms Governing BubR1 Protein Stability During Stress and AgingR01AG077574 · NIA · CREIGHTON UNIVERSITY · PI Brian J. North · 2022 to 2026
$1.5M
NIA NIH HHS R01 AG077574
6 · The paper itself

Abstract

Aging is a significant risk factor for cancer which is due, in part, to heightened genomic instability. Mitotic surveillance proteins such as BubR1 play a pivotal role in ensuring accurate chromosomal segregation and preventing aneuploidy. BubR1 levels have been shown to naturally decline with age and its loss is associated with various age-related pathologies. Sirtuins, a class of NAD

Indexed as

AgingAneuploidyNeoplasmsProtein Serine-Threonine KinasesSirtuin 2AnimalsCellular SenescenceGenomic InstabilityHumansBUB1 protein, humanProtein Serine-Threonine KinasesSIRT2 protein, humanSirtuin 2AgingAneuploidyBubR1CancerSenescenceSIRT2Sirtuins

Identifiers

PMID39490401
PMCPMC11625622

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.