Evidence map›Paper›PMID 39490337›Full record

ReviewTrends in genetics : TIG2025

Crossover recombination between homologous chromosomes in meiosis: recent progress and remaining mysteries.

Lisette Payero, Eric Alani

Abstract readReview
In one paragraph

Review in Trends in genetics : TIG, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Host skin lipids triggerbioRxiv : the preprint server for biology · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. A homozygousFrontiers in endocrinology · 2026
    Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Lisette PayeroDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA.
Eric AlaniDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA. Electronic address: eea3@cornell.edu.

Funding

Roles for Mismatch Repair Proteins in Maintaining Genome StabilityR35GM134872 · NIGMS · CORNELL UNIVERSITY · PI Eric E. Alani · 2020 to 2026
$2.8M
Uncovering the Role of Exo1 in Meiotic RecombinationF31GM145163 · NIGMS · CORNELL UNIVERSITY · PI PAYERO, LISETTE · 2022 to 2024
$98k
NIGMS NIH HHS F31 GM145163NIGMS NIH HHS R35 GM134872
6 · The paper itself

Abstract

Crossing over between homologous chromosomes in meiosis is essential in most eukaryotes to produce gametes with the correct ploidy. Meiotic crossovers are typically evenly spaced, with each homolog pair receiving at least one crossover. The association of crossovers with distal sister chromatid cohesion is critical for the proper segregation of homologs in the first meiotic division. Studies in baker's yeast (Saccharomyces cerevisiae) have shown that meiotic crossovers result primarily from the biased resolution of double Holliday junction (dHJ) recombination intermediates through the actions of factors that belong to the DNA mismatch repair family. These findings and studies involving fine-scale mapping of meiotic crossover events have led to a new generation of mechanistic models for crossing over that are currently being tested.

Indexed as

Crossing Over, GeneticMeiosisSaccharomyces cerevisiaeAnimalsChromosomesChromosome SegregationDNA, CruciformHomologous RecombinationHumansDNA, Cruciformbiased resolutioncrossing overdouble Holliday junctionsmeiosis

Identifiers

PMID39490337
PMCPMC12369570

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.