Evidence map›Paper›PMID 39490313›Full record

ArticleRedox biology2024

Disruption of canonical AHR-mediated induction of hepatocyte PKM2 expression compromises antioxidant defenses and increases TCDD-induced hepatotoxicity.

Karina Orlowska, Rance Nault, Jesmin Ara, John J LaPres, Jack Harkema, Elena Y Demireva, Huirong Xie, Rachel H Wilson, Christopher A Bradfield, Dianne Yap and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Karina OrlowskaBiochemistry & Molecular Biology, Michigan State University, East Lansing, MI, 48824, USA; Institute for Integrative Toxicology, Michigan State University, East Lansing, MI, 48824, USA.
Rance NaultBiochemistry & Molecular Biology, Michigan State University, East Lansing, MI, 48824, USA; Institute for Integrative Toxicology, Michigan State University, East Lansing, MI, 48824, USA; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, 48824, USA.
Jesmin AraBiochemistry & Molecular Biology, Michigan State University, East Lansing, MI, 48824, USA.
John J LaPresBiochemistry & Molecular Biology, Michigan State University, East Lansing, MI, 48824, USA; Institute for Integrative Toxicology, Michigan State University, East Lansing, MI, 48824, USA.
Jack HarkemaDepartment of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, 48824, USA; Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI, 48824, USA.
Elena Y DemirevaTransgenic and Genome Editing Facility, Michigan State University, East Lansing, MI, 48824, USA; Institute for Quantitative Health Science & Engineering, Michigan State University, East Lansing, MI, 48824, USA.
Huirong XieTransgenic and Genome Editing Facility, Michigan State University, East Lansing, MI, 48824, USA; Institute for Quantitative Health Science & Engineering, Michigan State University, East Lansing, MI, 48824, USA.
Rachel H WilsonMcArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Christopher A BradfieldMcArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Dianne YapDepartment of Pharmacology and Toxicology, The University of Texas Medical Branch at Galveston, Galveston, TX, 77550, USA.
Aditya JoshiDepartment of Pharmacology and Toxicology, The University of Texas Medical Branch at Galveston, Galveston, TX, 77550, USA.
Cornelis J ElferinkDepartment of Pharmacology and Toxicology, The University of Texas Medical Branch at Galveston, Galveston, TX, 77550, USA.
Tim ZacharewskiBiochemistry & Molecular Biology, Michigan State University, East Lansing, MI, 48824, USA; Institute for Integrative Toxicology, Michigan State University, East Lansing, MI, 48824, USA. Electronic address: tzachare@msu.edu.

Funding

Novel Mechanism of aryl hydrocarbon receptor-mediated differential gene regulationR01DK122028 · NIDDK · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Aditya D Joshi · 2019 to 2026
$2.3M
Hepatic Aryl Hydrocarbon Receptor Regulation of Obesity: Mechanisms of ActionR01ES033682 · NIEHS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Casey W Wright · 2022 to 2026
$1.8M
NIEHS NIH HHS R01 ES033682
6 · The paper itself

Abstract

Metabolic reprogramming by the pyruvate kinase M2 isoform is associated with cell proliferation and reactive oxygen species (ROS) defenses. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), an environmental contaminant that induces ROS and hepatotoxicity, dose-dependently induces pyruvate kinase muscle isoform M2 (PKM2) in the liver. To further investigate its role in combating TCDD hepatotoxicity, a Pkm

Indexed as

HepatocytesPolychlorinated DibenzodioxinsPyruvate KinaseReactive Oxygen SpeciesReceptors, Aryl HydrocarbonAnimalsAntioxidantsBasic Helix-Loop-Helix ProteinsChemical and Drug Induced Liver InjuryGlutathioneHumansLiverMaleMiceMice, KnockoutOxidative StressAhr protein, mouseAntioxidantsBasic Helix-Loop-Helix ProteinsGlutathionePkm protein, mousePolychlorinated DibenzodioxinsPyruvate KinaseReactive Oxygen SpeciesReceptors, Aryl HydrocarbonThyroid Hormone-Binding ProteinsThyroid Hormones

Identifiers

PMID39490313
PMCPMC11543540

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.