Evidence map›Paper›PMID 39489871›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2025

Experience of rescue therapy with [

Alexander Gäble, Alexander Dierks, Andreas Rinscheid, Marianne Patt, Georgine Wienand, Christian H Pfob, Malte Kircher, Kazuhito Fukushima, Ana Antić Nikolić, Johanna S Enke and 7 more

Abstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Alexander Gäble *Nuclear Medicine, Faculty of Medicine, University of Augsburg, Augsburg, Germany.
Alexander Dierks *Nuclear Medicine, Faculty of Medicine, University of Augsburg, Augsburg, Germany.
Andreas RinscheidMedical Physics and Radiation Protection, University Hospital Augsburg, Augsburg, Germany.
Marianne PattNuclear Medicine, Faculty of Medicine, University of Augsburg, Augsburg, Germany.
Georgine WienandNuclear Medicine, Faculty of Medicine, University of Augsburg, Augsburg, Germany.
Christian H PfobNuclear Medicine, Faculty of Medicine, University of Augsburg, Augsburg, Germany.
Malte KircherNuclear Medicine, Faculty of Medicine, University of Augsburg, Augsburg, Germany.
Kazuhito FukushimaRadiology, Kobe International Collaboration Clinic, Kobe, Japan.
Ana Antić NikolićNuclear Medicine, Faculty of Medicine, University of Augsburg, Augsburg, Germany.
Johanna S EnkeNuclear Medicine, Faculty of Medicine, University of Augsburg, Augsburg, Germany.
Tilman JanzenMedical Physics and Radiation Protection, University Hospital Augsburg, Augsburg, Germany.
Julie SteinestelBavarian Cancer Research Center (BZKF), Augsburg, Germany.
Hildegard KempterBavarian Cancer Research Center (BZKF), Augsburg, Germany.
Martin TrepelBavarian Cancer Research Center (BZKF), Augsburg, Germany.
Dorothea WeckermannBavarian Cancer Research Center (BZKF), Augsburg, Germany.
Constantin Lapa *Nuclear Medicine, Faculty of Medicine, University of Augsburg, Augsburg, Germany.
Ralph A Bundschuh *Nuclear Medicine, Faculty of Medicine, University of Augsburg, Augsburg, Germany. Ralph.Bundschuh@gmx.de.ORCID 0000-0001-7291-9372

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeRadioligand therapy is an increasingly important option for the treatment of metastatic castrate-resistant prostate cancer (mCRPC). Radiohybrid ligands targeting prostate-specific membrane antigen (PSMA) are a novel group of theranostic radioligand therapy agents for which higher tumour absorbed radiation doses have been demonstrated compared to established PSMA ligands. Here, we report data from ten patients who were treated within a compassionate use program with the radiohybrid PSMA-ligand [

methodsTen patients with advanced PSMA-positive prostate cancer who showed progression under treatment with [

resultsDespite progression with [

conclusionsPatients showing tumour progression while receiving [

Indexed as

Antigens, SurfaceAntineoplastic AgentsDrug Resistance, NeoplasmGlutamate Carboxypeptidase IILutetiumProstatic Neoplasms, Castration-ResistantRadioisotopesHumansMaleNeoplasm MetastasisPositron Emission Tomography Computed TomographyRecombinant ProteinsSalvage TherapyAntigens, SurfaceAntineoplastic AgentsFOLH1 protein, humanGlutamate Carboxypeptidase IILutetiumLutetium-177RadioisotopesRecombinant ProteinsProstate cancerProstate-specific membrane antigenRadiohybrid ligandsRadioligand therapyTherapeutic response

Identifiers

PMID39489871
PMCPMC11754363

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.