Evidence map›Paper›PMID 39489865›Full record

ArticleScientific reports2024

Oral N-acetylcysteine ameliorates liver fibrosis and enhances regenerative responses in Mdr2 knockout mice.

Adi Har-Zahav, Ana Tobar, Sophia Fried, Rachel Sivan, Benjamin J Wilkins, Pierre Russo, Raanan Shamir, Rebecca G Wells, Michael Gurevich, Orith Waisbourd-Zinman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Adi Har-ZahavInstitute of Gastroenterology, Hepatology and Nutrition, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.
Ana TobarFaculty of Medicine, Felsenstein Medical Research Center Tel-Aviv University, Tel-Aviv, Israel.
Sophia FriedInstitute of Gastroenterology, Hepatology and Nutrition, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.
Rachel SivanInstitute of Gastroenterology, Hepatology and Nutrition, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.
Benjamin J WilkinsDepartment of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Pierre RussoDepartment of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Raanan ShamirInstitute of Gastroenterology, Hepatology and Nutrition, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.
Rebecca G WellsDepartments of Medicine, Bioengineering, and Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Michael GurevichThe Organ Transplantation Division, Schneider Children's Medical Center, Petach Tikva, Israel.
Orith Waisbourd-ZinmanInstitute of Gastroenterology, Hepatology and Nutrition, Schneider Children's Medical Center of Israel, Petach Tikva, Israel. orithw@tauex.tau.ac.il.

Funding

PSC Partners Seeking a Cure 72-12The Israeli Science Foundation 1879/21
6 · The paper itself

Abstract

Cholangiopathies are poorly understood disorders with no effective therapy. The extrahepatic biliary tree phenotype is less studied compared to the intrahepatic biliary injury in both human disease and Mdr2

Indexed as

AcetylcysteineATP-Binding Cassette Sub-Family B Member 4ATP Binding Cassette Transporter, Subfamily BLiver CirrhosisAdministration, OralAnimalsDisease Models, AnimalLiverLiver RegenerationMaleMiceMice, KnockoutAcetylcysteineATP-Binding Cassette Sub-Family B Member 4ATP Binding Cassette Transporter, Subfamily BBile duct repairCholangiopathyMdr2−/−NAC

Identifiers

PMID39489865
PMCPMC11532366

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.