ArticleInternational journal of computer assisted radiology and surgery2025
Artificial intelligence-based analysis of lower limb muscle mass and fatty degeneration in patients with knee osteoarthritis and its correlation with Knee Society Score.
Article in International journal of computer assisted radiology and surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Automated framework for volumetric musculoskeletal segmentation and assessment of torso CT images in large-scale databases.International journal of computer assisted radiology and surgery · 2026Article
- Three-dimensional artificial intelligence-based computed tomography analysis of lower limb muscle volume and fatty degeneration in varus and valgus knee osteoarthritis: a single-center retrospective study.BMC musculoskeletal disorders · 2026Article
- 3D CSFA-UNet: a unified attention-driven deep learning framework for accurate knee MRI segmentation and osteoarthritis severity classification.Scientific reports · 2026Article
- Lower-limb muscle mass quantification and whole-body muscle loss detection using preoperative computed tomography images in patients with hip disease.International journal of computer assisted radiology and surgery · 2025Article
- Handgrip and contralateral knee flexion strength as key predictors of daily physical activity in severe knee osteoarthritis.Journal of experimental orthopaedics · 2025Article
- Varus deformity in medial knee osteoarthritis correlates with fatty degeneration of lower limb muscles: Artificial intelligence-based computed tomography analysis.Journal of experimental orthopaedics · 2025Article
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12 authors.
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Abstract
purposeLower-limb muscle mass reduction and fatty degeneration develop in patients with knee osteoarthritis (KOA) and could affect their symptoms, satisfaction, expectation and functional activities. The Knee Society Scoring System (KSS) includes patient reported outcome measures, which is widely used to evaluate the status of knee function of KOA. This study aimed to clarify how muscle mass and fatty degeneration of the lower limb correlate with the KSS in patients with KOA.
methodsThis study included 43 patients with end-stage KOA, including nine males and 34 females. Computed tomography (CT) images of the lower limb obtained for the planning of total knee arthroplasty were utilized. Ten muscle groups were segmented using our artificial-intelligence-based methods. Muscle volume was standardized by dividing by their height squared. The mean CT value for each muscle group was calculated as an index of fatty degeneration. Bivariate analysis between muscle volume or CT values and KSS was performed using Spearman's rank correlation test. Multiple regression analysis was performed, and statistical significance was set at p < 0.05.
resultsBivariate analysis showed that the functional activity score was significantly correlated with the mean CT value of all muscle groups except the adductors and iliopsoas. Multiple regression analysis revealed that the functional activities score was significantly associated with the mean CT values of the gluteus medius and minimus muscles and the anterior and lateral compartments of the lower leg (β = 0.42, p = 0.01; β = 0.33, p = 0.038; and β = 0.37, p = 0.014, respectively).
conclusionFatty degeneration, rather than muscle mass, in the lower-limb muscles was significantly associated with functional activities score of the KSS in patients with end-stage KOA. Notably, the gluteus medius and minimus and the anterior and lateral compartments of the lower leg are important muscles associated with functional activities.
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