Evidence map›Paper›PMID 39489724›Full record

SynthesisOral diseases2025

Automated Detection of Oral Malignant Lesions Using Deep Learning: Scoping Review and Meta-Analysis.

Olga Di Fede, Gaetano La Mantia, Marco Parola, Laura Maniscalco, Domenica Matranga, Pietro Tozzo, Giuseppina Campisi, Mario G C A Cimino

Abstract readMeta-AnalysisScoping Review
In one paragraph

Synthesis in Oral diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Olga Di FedeDepartment of Precision Medicine in Medical, Surgical and Critical Care (Me.Pre.C.C.), University of Palermo, Palermo, Italy.ORCID https://orcid.org/0000-0002-5562-7420
Gaetano La MantiaDepartment of Precision Medicine in Medical, Surgical and Critical Care (Me.Pre.C.C.), University of Palermo, Palermo, Italy.ORCID https://orcid.org/0000-0002-3135-7462
Marco ParolaDepartment of Information Engineering, University of Pisa, Pisa, Italy.ORCID https://orcid.org/0000-0003-4871-4902
Laura ManiscalcoDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy.ORCID https://orcid.org/0000-0001-7974-3963
Domenica MatrangaDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy.ORCID https://orcid.org/0000-0002-2466-937X
Pietro TozzoUnit of Stomatology, Ospedali Riuniti "Villa Sofia-Cervello" of Palermo, Palermo, Italy.ORCID https://orcid.org/0000-0002-8453-0206
Giuseppina CampisiUnit of Oral Medicine and Dentistry for Fragile Patients, Department of Rehabilitation, Fragility, and Continuity of Care, University Hospital Palermo, Palermo, Italy.ORCID https://orcid.org/0000-0002-9443-0495
Mario G C A CiminoDepartment of Information Engineering, University of Pisa, Pisa, Italy.ORCID https://orcid.org/0000-0002-1031-1959

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveOral diseases, specifically malignant lesions, are serious global health concerns requiring early diagnosis for effective treatment. In recent years, deep learning (DL) has emerged as a powerful tool for the automated detection and classification of oral lesions. This research, by conducting a scoping review and meta-analysis, aims to provide an overview of the progress and achievements in the field of automated detection of oral lesions using DL. MATERIALS AND

methodsA scoping review was conducted to identify relevant studies published in the last 5 years (2018-2023). A comprehensive search was conducted using several electronic databases, including PubMed, Web of Science, and Scopus. Two reviewers independently assessed the studies for eligibility and extracted data using a standardized form, and a meta-analysis was conducted to synthesize the findings.

resultsFourteen studies utilizing various DL algorithms were identified and included for the detection and classification of oral lesions from clinical images. Among these, three were included in the meta-analysis. The estimated pooled sensitivity and specificity were 0.86 (95% confidence interval [CI] = 0.80-0.91) and 0.67 (95% CI = 0.58-0.75), respectively.

conclusionsThe results of meta-analysis indicate that DL algorithms improve the diagnosis of oral lesions. Future research should develop validated algorithms for automated diagnosis.

trial registrationOpen Science Framework (https://osf.io/4n8sm).

Indexed as

Deep LearningMouth NeoplasmsHumansSensitivity and Specificityautomatic detectionconvolutional neural networksdeep learningmeta‐analysisoral canceroral lesion classification

Identifiers

PMID39489724
PMCPMC12022385

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.